TY - JOUR
T1 - Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells
AU - Lu, Guo Liang
AU - Ho, Cheuk Lam
AU - Wang, Qiwei
AU - Wong, Wai Yeung
AU - Chui, Chung Hin
AU - Wong, Raymond Siu Ming
AU - Gambari, Roberto
AU - Lau, Fung Yi
AU - Yuen, Marcus Chun Wah
AU - Tong, Cindy Sze Wai
AU - Chan, Andrew Kit Wah
AU - Tang, Cheuk On
AU - Ho, Kwok Ping
AU - Cheng, Gregory Yin Ming
PY - 2008/12/22
Y1 - 2008/12/22
N2 - Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials.
AB - Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials.
UR - http://www.scopus.com/inward/record.url?scp=57649228057&partnerID=8YFLogxK
U2 - 10.1071/CH08342
DO - 10.1071/CH08342
M3 - Journal article
VL - 61
SP - 975
EP - 980
JO - Australian Journal of Chemistry
JF - Australian Journal of Chemistry
SN - 0004-9425
IS - 12
ER -