Synthesis and characterization of some metal complexes of 4,5-diazafluoren-9-one and their biological effects on human carcinoma cells

Guo Liang Lu, Cheuk Lam Ho, Qiwei Wang, Wai Yeung Wong, Chung Hin Chui, Raymond Siu Ming Wong, Roberto Gambari, Fung Yi Lau, Marcus Chun Wah Yuen, Cindy Sze Wai Tong, Andrew Kit Wah Chan, Cheuk On Tang, Kwok Ping Ho, Gregory Yin Ming Cheng

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Three new transition metal complexes of 4,5-diazafluoren-9-one, [(DAFO)PdCl2], [(DAFO)PtCl2], and [(DAFO)ZnCl2], were prepared in good yields by the reactions between appropriate metal chloride precursors and 4,5-diazafluoren-9-one under ambient conditions. The structures of these metal complexes were established by spectroscopic (Fourier-transform IR, NMR, and fast-atom bombardment mass spectrometry) techniques. The possible biological activity of these compounds on three human cancer cell lines including Hep3B, MDAMB-231, and SKHep-1 was investigated. The results obtained showed that both zinc- and platinum-containing compounds exhibit a similar growth inhibitory effect on these three cancer cell lines when compared with the prototypical cis-platin. In contrast, the corresponding palladium congener is virtually biologically inactive in these trials.
Original languageEnglish
Pages (from-to)975-980
Number of pages6
JournalAustralian Journal of Chemistry
Issue number12
Publication statusPublished - 22 Dec 2008

ASJC Scopus subject areas

  • Chemistry(all)

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