Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines

Stanton Hon Lung Kok, Roberto Gambari, Chung Hin Chui, Marcus Chun Wah Yuen, Eva Lin, Raymond Siu Ming Wong, Fung Yi Lau, Gregory Yin Ming Cheng, Wing Sze Lam, Sau Hing Chan, Kim Hung Lam, Chor Hing Cheng, Paul Bo Shan Lai, Michael Wing Yiu Yu, Filly Cheung, Cheuk On Tang, Albert Sun Chi Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

166 Citations (Scopus)

Abstract

Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.
Original languageEnglish
Pages (from-to)3626-3631
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number7
DOIs
Publication statusPublished - 1 Apr 2008

Keywords

  • Antiproliferation
  • Benzothiazole
  • Neoplasm
  • Phthalimide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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