Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines

Stanton Hon Lung Kok; Roberto Gambari; Chung Hin Chui; Marcus Chun Wah Yuen; Eva Lin; Raymond Siu Ming Wong; Fung Yi Lau; Gregory Yin Ming Cheng; Wing Sze Lam; Sau Hing Chan; Kim Hung Lam; Chor Hing Cheng; Paul Bo Shan Lai; Michael Wing Yiu Yu; Filly Cheung; Cheuk On Tang; Albert Sun Chi Chan

doi:10.1016/j.bmc.2008.02.005

Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines

Stanton Hon Lung Kok, Roberto Gambari, Chung Hin Chui, Marcus Chun Wah Yuen, Eva Lin, Raymond Siu Ming Wong, Fung Yi Lau, Gregory Yin Ming Cheng, Wing Sze Lam, Sau Hing Chan, Kim Hung Lam, Chor Hing Cheng, Paul Bo Shan Lai, Michael Wing Yiu Yu, Filly Cheung, Cheuk On Tang, Albert Sun Chi Chan

Research output: Journal article publication › Journal article › Academic research › peer-review

206 Citations (Scopus)

Abstract

Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.

Original language	English
Pages (from-to)	3626-3631
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	7
DOIs	https://doi.org/10.1016/j.bmc.2008.02.005
Publication status	Published - 1 Apr 2008

Keywords

Antiproliferation
Benzothiazole
Neoplasm
Phthalimide

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1016/j.bmc.2008.02.005

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Kok, S. H. L., Gambari, R., Chui, C. H., Yuen, M. C. W., Lin, E., Wong, R. S. M., Lau, F. Y., Cheng, G. Y. M., Lam, W. S., Chan, S. H., Lam, K. H., Cheng, C. H., Lai, P. B. S., Yu, M. W. Y., Cheung, F., Tang, C. O., & Chan, A. S. C. (2008). Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines. Bioorganic and Medicinal Chemistry, 16(7), 3626-3631. https://doi.org/10.1016/j.bmc.2008.02.005

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abstract = "Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.",

keywords = "Antiproliferation, Benzothiazole, Neoplasm, Phthalimide",

author = "Kok, {Stanton Hon Lung} and Roberto Gambari and Chui, {Chung Hin} and Yuen, {Marcus Chun Wah} and Eva Lin and Wong, {Raymond Siu Ming} and Lau, {Fung Yi} and Cheng, {Gregory Yin Ming} and Lam, {Wing Sze} and Chan, {Sau Hing} and Lam, {Kim Hung} and Cheng, {Chor Hing} and Lai, {Paul Bo Shan} and Yu, {Michael Wing Yiu} and Filly Cheung and Tang, {Cheuk On} and Chan, {Albert Sun Chi}",

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doi = "10.1016/j.bmc.2008.02.005",

language = "English",

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Kok, SHL, Gambari, R, Chui, CH, Yuen, MCW, Lin, E, Wong, RSM, Lau, FY, Cheng, GYM, Lam, WS, Chan, SH, Lam, KH, Cheng, CH, Lai, PBS, Yu, MWY, Cheung, F, Tang, CO & Chan, ASC 2008, 'Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines', Bioorganic and Medicinal Chemistry, vol. 16, no. 7, pp. 3626-3631. https://doi.org/10.1016/j.bmc.2008.02.005

TY - JOUR

T1 - Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines

AU - Kok, Stanton Hon Lung

AU - Gambari, Roberto

AU - Chui, Chung Hin

AU - Yuen, Marcus Chun Wah

AU - Lin, Eva

AU - Wong, Raymond Siu Ming

AU - Lau, Fung Yi

AU - Cheng, Gregory Yin Ming

AU - Lam, Wing Sze

AU - Chan, Sau Hing

AU - Lam, Kim Hung

AU - Cheng, Chor Hing

AU - Lai, Paul Bo Shan

AU - Yu, Michael Wing Yiu

AU - Cheung, Filly

AU - Tang, Cheuk On

AU - Chan, Albert Sun Chi

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.

AB - Phthalic anhydride is a highly toxic substance, facing, however, the problem of hydrolysis. In fact, it is rapidly hydrolyzed in aqueous medium, generating phthalic acid as the final product, which is almost harmless to viable cells. Here we describe the 'one pot' condensation reaction for the synthesis of phthalic imide derivative (benzothiazole containing phthalimide), exhibiting in vitro cytotoxic potential on human cancer cell lines. We further demonstrated that both caspase-dependent and -independent pathways are involved in our novel benzothiazole containing phthalimide induced apoptosis on cancer cells.

KW - Antiproliferation

KW - Benzothiazole

KW - Neoplasm

KW - Phthalimide

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U2 - 10.1016/j.bmc.2008.02.005

DO - 10.1016/j.bmc.2008.02.005

M3 - Journal article

C2 - 18295491

SN - 0968-0896

VL - 16

SP - 3626

EP - 3631

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 7

ER -

Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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