Synergistic effect of VEGF and BMP4 incorporated hydrogel in osteogenesis of non-decorticated posterior spinal fusion

J. C. Cheng, H. Y. Yeung, K. M. Lee, Y. M. Chiu, L. Qin, Xia Guo, P. Chow, Y. Tabata

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review


The combined osteogenic effect of BMP4 and VEGF delivered by hydrogel in posterior spinal fusion was evaluated. For the study, 12 NZW rabbits divided into four groups and each animal in each group underwent standardized bilateral non-decorticated posterior intertransverse process spinal fusion at L5-L6 lumber spinal, and implanted with different grafting materials. It was observed that when BMP4 was added to the fusion site, the bone was formed only around the transverse process. It was suggested that the combination of VEGF and BMO4 with hydrogel opens a new channel for developing new composites for spinal fusion enhancement.
Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - 1 Dec 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004


ConferenceTransactions - 7th World Biomaterials Congress

ASJC Scopus subject areas

  • Engineering(all)

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