Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer: CHEST Guideline and Expert Panel Report

Alexandros Molasiotis, Jaclyn A. Smith, Peter Mazzone, Fiona Blackhall, Richard S. Irwin, Todd M. Adams, Kenneth W. Altman, Alan F. Barker, Surinder S. Birring, Fiona Blackhall, Donald C. Bolser, Louis Philippe Boulet, Sidney S. Braman, Christopher Brightling, Priscilla Callahan-Lyon, Brendan J. Canning, Anne B. Chang, Terrie Cowley, Paul Davenport, Satoru EbiharaAli A. El Solh, Patricio Escalante, Stephen K. Field, Dina Fisher, Cynthia T. French, Peter Gibson, Philip Gold, Cameron Grant, Anthony Harnden, Adam T. Hill, Richard S. Irwin, Peter J. Kahrilas, Karina A. Keogh, Kefang Lai, Andrew P. Lane, Mark A. Malesker, Peter Mazzone, Stuart Mazzone, Alex Molassiotis, M. Hassan Murad, Peter Newcombe, Huong Q. Nguyen, John Oppenheimer, Marcos I. Restrepo, Mark Rosen, Bruce Rubin, Jay H. Ryu, Jaclyn Smith, Susan M. Tarlo, Julie Turmel, Anne E. Vertigan, Miles M. Weinberger, Kelly Weir

Research output: Journal article publicationJournal articleAcademic researchpeer-review

36 Citations (Scopus)


We used a 2015 Cochrane systematic review, among other sources of evidence, to update the recommendations and suggestions of the American College of Chest Physicians (CHEST) 2006 guideline on this topic. Methods The CHEST methodologic guidelines and the Grading of Recommendations, Assessment, Development, and Evaluation framework were used. The Expert Cough Panel based their recommendations on data from the Cochrane systematic review on the topic, uncontrolled studies, case studies, and the clinical context. Final grading was reached by consensus according to the Delphi method. Results The Cochrane systematic review identified 17 trials of primarily low-quality evidence. Such evidence was related to both nonpharmacologic (cough suppression) and pharmacologic (demulcents, opioids, peripherally acting antitussives, or local anesthetics) treatments, as well as endobronchial brachytherapy. Conclusions Compared with the 2006 CHEST Cough Guideline, the current recommendations and suggestions are more specific and follow a step-up approach to the management of cough among patients with lung cancer, acknowledging the low-quality evidence in the field and the urgent need to develop more effective, evidence-based interventions through high-quality research.
Original languageEnglish
Pages (from-to)861-874
Number of pages14
Issue number4
Publication statusPublished - 1 Apr 2017


  • cough
  • evidence-based medicine
  • guidelines
  • lung cancer

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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