Swelling observation and modulus extraction of cartilage based on transient ultrasonic

Haijun Niu, Yongping Zheng, Qing Wang, Fang Pu, Deyu Li, Yubo Fan

Research output: Journal article publicationJournal articleAcademic researchpeer-review


Subtle changes in structure or composition can lead to degeneration of articular cartilage such as in osteoarthritis, so it is significant to study the materials attribute of the degenerating articular cartilage. A new transient ultrasonic technique was introduced into this study for measuring the swelling effects of the degenerated cartilage. The swelling-induced strain was calculated based on the measurement result, and then the uniaxial module of the articular cartilag was extracted using Narmoneva's triphasic model. The ultrasonic observation showed that the strains induced by the nonuniform swelling are depth-dependent, and the strains are small in the deep zone and big in the middle and surface zones. The uniaxial modulus also revealed that the cartilage in the deep zone (E1 = 12.20) is harder than that in surface zone (E2 = 0.15). These results suggest that the transient ultrasound technique accompanied by triphasic model provides a quantitative means to study the degeneration of articular cartilage.
Original languageEnglish
Pages (from-to)822-825
Number of pages4
JournalSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Issue number4
Publication statusPublished - 1 Aug 2008
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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