Suzuki-Miyaura coupling of aryl tosylates catalyzed by an array of indolyl phosphine-palladium catalysts

Chau Ming So, Chak Po Lau, Albert S.C. Chan, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

118 Citations (Scopus)

Abstract

(Chemical Equation Presented) A family of indolyl phosphine ligands was applied to Suzuki-Miyaura cross-coupling of aryl tosylates. Catalyst loading can be reduced to 0.2 mol % for coupling of nonactivated aryl tosylate. A challenging example for room temperature coupling is realized. The scope of this highly active Pd/L2 system can be extended to other boron nucleophiles, including trifluoroborate salts and boronate esters. The ligand structural comparisons toward the reactivity in tosylate couplings are also described.

Original languageEnglish
Pages (from-to)7731-7734
Number of pages4
JournalJournal of Organic Chemistry
Volume73
Issue number19
DOIs
Publication statusPublished - 3 Oct 2008

ASJC Scopus subject areas

  • Organic Chemistry

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