TY - GEN
T1 - Surface coating of poly-D-L-lactide/nano-hydroxyapatite composite scaffolds for dexamethasone-releasing function and wettability enhancement
AU - Chen, Ling
AU - Tang, Chak Yin
AU - Ku, Harry Siu Lung
AU - Chen, Da Zhu
AU - Tsui, Chi Pong
PY - 2013/8/5
Y1 - 2013/8/5
N2 - Biodegradable polymeric nano-composite scaffolds have recently attracted considerable attention in curing bone deficiencies resulting from fractures or traumas. In this article, the latest progress in fabrication and characterization of poly-D-L-lactide/nano-hydroxyapatite (PDLLA/nano-HA) composite scaffolds, with poly (ethylene glycol) (PEG)-coating and dexamethasone (Dex)-releasing for bone tissue engineering is presented. For the design of drug release scaffolds, some aspects related to the choice of polymer matrix, bioactive inclusions, drug release coatings, and fabrication techniques are firstly reviewed. A PEG-based coating method was subsequently developed to modify a biodegradable polymeric nano-composite scaffold in providing a drug release function with improved wettability. The changes of water contact angle of the scaffolds before and after PEG/Dex coating were measured and the drug release function of the PEG/Dex coating was studied. The experimental findings showed that the proposed coating method was effective in enhancing the wettability and in controlling the early stage of drug release of the PDLLA/nano-HA composite scaffold.
AB - Biodegradable polymeric nano-composite scaffolds have recently attracted considerable attention in curing bone deficiencies resulting from fractures or traumas. In this article, the latest progress in fabrication and characterization of poly-D-L-lactide/nano-hydroxyapatite (PDLLA/nano-HA) composite scaffolds, with poly (ethylene glycol) (PEG)-coating and dexamethasone (Dex)-releasing for bone tissue engineering is presented. For the design of drug release scaffolds, some aspects related to the choice of polymer matrix, bioactive inclusions, drug release coatings, and fabrication techniques are firstly reviewed. A PEG-based coating method was subsequently developed to modify a biodegradable polymeric nano-composite scaffold in providing a drug release function with improved wettability. The changes of water contact angle of the scaffolds before and after PEG/Dex coating were measured and the drug release function of the PEG/Dex coating was studied. The experimental findings showed that the proposed coating method was effective in enhancing the wettability and in controlling the early stage of drug release of the PDLLA/nano-HA composite scaffold.
UR - http://www.scopus.com/inward/record.url?scp=84884641530&partnerID=8YFLogxK
U2 - 10.1002/9781118751015.ch4
DO - 10.1002/9781118751015.ch4
M3 - Conference article published in proceeding or book
AN - SCOPUS:84884641530
SN - 9781118751039
VL - 242
T3 - Ceramic Transactions
SP - 29
EP - 36
BT - Biomaterials Science: Processing, Properties and Applications III
T2 - Next Generation Biomaterials and Surface Properties of Biomaterials Symposia - Materials Science and Technology 2012 Conference, MS and T 2012
Y2 - 27 October 2012 through 31 October 2012
ER -