Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis

Daojuan Wang, Tingyu Wang, Rong Wang, Xinlin Zhang, Lei Wang, Zou Xiang, Lingjia Zhuang, Shanmei Shen, Hongwei Wang, Qian Gao, Yong Wang

Research output: Journal article publicationJournal articleAcademic researchpeer-review


Rats with hyperandrogen-induced polycystic ovary syndrome (PCOS) have been shown to develop ovarian oxidative stress (OS) and fibrosis. The Sirt1 agonist, resveratrol, can reduce OS through inhibiting p66Shc in other models of OS.
Original languageEnglish
JournalJournal of Translational Medicine
Issue number1
Publication statusPublished - 17 Feb 2020

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