Subclinical decrease in central inner retinal activity is associated with myopia development in children

Serena Zhe Chuang Li, Wing Yan Yu, Kai Yip Choi, Christie Hang I. Lam, Yamunadevi Lakshmanan, Francisca Siu Yin Wong, Henry Ho Lung Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

12 Citations (Scopus)


PURPOSE. To investigate the characteristics of retinal electrophysiological activity in relation to early myopia development in children. METHODS. Fifty-six children aged 6 to 9 years with emmetropic refractive error (defined as ≥ -0.5 diopter [D] and ≤ +0.5 D) were recruited. Cycloplegic refraction, axial length, and global flash multifocal electroretinogram (MOFO mfERG) at 49% and 96% contrast levels were recorded in all children at their first visit. The refraction and axial length measurements were repeated after 1 year. The amplitudes and implicit times of the direct component (DC) and the induced component (IC) of the MOFO mfERG obtained at the initial visit were analyzed. Correlations between the MOFO mfERG parameters and changes in refractive error and axial length were investigated. RESULTS. The mean spherical equivalent refractive error and axial length of the eyes of the children at the first visit were +0.19 ± 0.33 D and 23.14 ± 0.6 mm, respectively. After 1 year, the mean refractive error increased by -0.55 ± 0.53 D, whereas axial length increased by 0.37 ± 0.22 mm. The changes in refractive error and axial length were significantly correlated with the central IC amplitudes at 49% contrast level measured at the initial visit (π = 0.46, P < 0.001 and π = -0.34, P = 0.01, respectively). CONCLUSIONS. The prospective changes we have shown are believed to derive from central inner retina. These changes appear to precede myopia and could be a potential reference for juvenile myopia development.

Original languageEnglish
Pages (from-to)4019-4026
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Issue number10
Publication statusPublished - Aug 2017


  • Children vision
  • Inner retina
  • Multifocal electroretinogram
  • Myopia development

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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