Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum

Yungen Liu; Chun Nam Lok; Chi Bun Ko; Tina Yuen Ting Shum; Man Kin Wong; Chi Ming Che

doi:10.1021/ol902890j

Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum

Yungen Liu, Chun Nam Lok, Chi Bun Ko, Tina Yuen Ting Shum, Man Kin Wong, Chi Ming Che

Research output: Journal article publication › Journal article › Academic research › peer-review

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Abstract

"Chemical eqation presented" A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and Its subcellular localization In Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) Is the main site of its accumulation.

Original language	English
Pages (from-to)	1420-1423
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	7
DOIs	https://doi.org/10.1021/ol902890j
Publication status	Published - 2 Apr 2010

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol902890j

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title = "Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum",

abstract = "{"}Chemical eqation presented{"} A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and Its subcellular localization In Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) Is the main site of its accumulation.",

author = "Yungen Liu and Lok, {Chun Nam} and Ko, {Chi Bun} and Shum, {Tina Yuen Ting} and Wong, {Man Kin} and Che, {Chi Ming}",

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AU - Liu, Yungen

AU - Lok, Chun Nam

AU - Ko, Chi Bun

AU - Shum, Tina Yuen Ting

AU - Wong, Man Kin

AU - Che, Chi Ming

PY - 2010/4/2

Y1 - 2010/4/2

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AB - "Chemical eqation presented" A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and Its subcellular localization In Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) Is the main site of its accumulation.

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U2 - 10.1021/ol902890j

DO - 10.1021/ol902890j

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SP - 1420

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JO - Organic Letters

JF - Organic Letters

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Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum

Abstract

ASJC Scopus subject areas

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