Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum

Yungen Liu, Chun Nam Lok, Chi Bun Ko, Tina Yuen Ting Shum, Man Kin Wong, Chi Ming Che

Research output: Journal article publicationJournal articleAcademic researchpeer-review

42 Citations (Scopus)

Abstract

"Chemical eqation presented" A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and Its subcellular localization In Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) Is the main site of its accumulation.
Original languageEnglish
Pages (from-to)1420-1423
Number of pages4
JournalOrganic Letters
Volume12
Issue number7
DOIs
Publication statusPublished - 2 Apr 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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