Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population

Huan Chen; Guoqing Wang; Jiguang Xia; Yuxi Zhou; Yong Gao; Junquan Xu; Michael S.Y. Huen; Wai Ting Siok; Yuyang Jiang; Li Hai Tan; Yimin Sun

doi:10.1186/1744-9081-10-29

Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population

Huan Chen, Guoqing Wang, Jiguang Xia, Yuxi Zhou, Yong Gao, Junquan Xu, Michael S.Y. Huen, Wai Ting Siok, Yuyang Jiang, Li Hai Tan (Corresponding Author), Yimin Sun (Corresponding Author)

Research output: Journal article publication › Journal article › Academic research › peer-review

16 Citations (Scopus)

Abstract

Background: Dyslexia is a polygenic developmental disorder characterized by difficulties in reading and spelling despite normal intelligence, educational backgrounds and perception. Increasing evidences indicated that dyslexia may share similar genetic mechanisms with other speech and language disorders. We proposed that stuttering candidate genes, DRD2 and SLC6A3, might be associated with dyslexia. Methods and results: The study was conducted in an unrelated Chinese cohort with 502 dyslexic cases and 522 healthy controls. In total, 23 Tag SNPs covering the two genes were selected for genotyping through Tagger program. Association analysis was performed on each SNP alone and in haplotypes. One SNP markers in DRD2 showed significant association with developmental dyslexia.Conclusion: These findings indicate that polymorphism of DRD2 gene may be a risk factor of developmental dyslexia in the Chinese population.

Original language	English
Article number	29
Journal	Behavioral and Brain Functions
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/1744-9081-10-29
Publication status	Published - 1 Sept 2014
Externally published	Yes

Keywords

Dopamine D2 receptor (DRD2)
Dyslexia
Linkage study
Solute carrier family 6, member 3 (SLC6A3)

ASJC Scopus subject areas

Cognitive Neuroscience
Biological Psychiatry
Behavioral Neuroscience

More information

10.1186/1744-9081-10-29

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title = "Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population",

abstract = "Background: Dyslexia is a polygenic developmental disorder characterized by difficulties in reading and spelling despite normal intelligence, educational backgrounds and perception. Increasing evidences indicated that dyslexia may share similar genetic mechanisms with other speech and language disorders. We proposed that stuttering candidate genes, DRD2 and SLC6A3, might be associated with dyslexia. Methods and results: The study was conducted in an unrelated Chinese cohort with 502 dyslexic cases and 522 healthy controls. In total, 23 Tag SNPs covering the two genes were selected for genotyping through Tagger program. Association analysis was performed on each SNP alone and in haplotypes. One SNP markers in DRD2 showed significant association with developmental dyslexia.Conclusion: These findings indicate that polymorphism of DRD2 gene may be a risk factor of developmental dyslexia in the Chinese population.",

keywords = "Dopamine D2 receptor (DRD2), Dyslexia, Linkage study, Solute carrier family 6, member 3 (SLC6A3)",

author = "Huan Chen and Guoqing Wang and Jiguang Xia and Yuxi Zhou and Yong Gao and Junquan Xu and Huen, {Michael S.Y.} and Siok, {Wai Ting} and Yuyang Jiang and Tan, {Li Hai} and Yimin Sun",

note = "Publisher Copyright: {\textcopyright} 2014 Chen et al.; licensee BioMed Central Ltd.",

year = "2014",

month = sep,

day = "1",

doi = "10.1186/1744-9081-10-29",

language = "English",

volume = "10",

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TY - JOUR

T1 - Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population

AU - Chen, Huan

AU - Wang, Guoqing

AU - Xia, Jiguang

AU - Zhou, Yuxi

AU - Gao, Yong

AU - Xu, Junquan

AU - Huen, Michael S.Y.

AU - Siok, Wai Ting

AU - Jiang, Yuyang

AU - Tan, Li Hai

AU - Sun, Yimin

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background: Dyslexia is a polygenic developmental disorder characterized by difficulties in reading and spelling despite normal intelligence, educational backgrounds and perception. Increasing evidences indicated that dyslexia may share similar genetic mechanisms with other speech and language disorders. We proposed that stuttering candidate genes, DRD2 and SLC6A3, might be associated with dyslexia. Methods and results: The study was conducted in an unrelated Chinese cohort with 502 dyslexic cases and 522 healthy controls. In total, 23 Tag SNPs covering the two genes were selected for genotyping through Tagger program. Association analysis was performed on each SNP alone and in haplotypes. One SNP markers in DRD2 showed significant association with developmental dyslexia.Conclusion: These findings indicate that polymorphism of DRD2 gene may be a risk factor of developmental dyslexia in the Chinese population.

AB - Background: Dyslexia is a polygenic developmental disorder characterized by difficulties in reading and spelling despite normal intelligence, educational backgrounds and perception. Increasing evidences indicated that dyslexia may share similar genetic mechanisms with other speech and language disorders. We proposed that stuttering candidate genes, DRD2 and SLC6A3, might be associated with dyslexia. Methods and results: The study was conducted in an unrelated Chinese cohort with 502 dyslexic cases and 522 healthy controls. In total, 23 Tag SNPs covering the two genes were selected for genotyping through Tagger program. Association analysis was performed on each SNP alone and in haplotypes. One SNP markers in DRD2 showed significant association with developmental dyslexia.Conclusion: These findings indicate that polymorphism of DRD2 gene may be a risk factor of developmental dyslexia in the Chinese population.

KW - Dopamine D2 receptor (DRD2)

KW - Dyslexia

KW - Linkage study

KW - Solute carrier family 6, member 3 (SLC6A3)

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U2 - 10.1186/1744-9081-10-29

DO - 10.1186/1744-9081-10-29

M3 - Journal article

C2 - 25178928

AN - SCOPUS:84908116314

SN - 1744-9081

VL - 10

JO - Behavioral and Brain Functions

JF - Behavioral and Brain Functions

IS - 1

M1 - 29

ER -

Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population

Abstract

Keywords

ASJC Scopus subject areas

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