Study protocol: A randomised controlled trial of the effects of a multi-modal exercise program on cognition and physical functioning in older women

S. Vaughan, N. Morris, Ho Keung David Shum, S. Odwyer, D. Polit

Research output: Journal article publicationJournal articleAcademic researchpeer-review

20 Citations (Scopus)


Background: Intervention studies testing the efficacy of cardiorespiratory exercise have shown some promise in terms of improving cognitive function in later life. Recent developments suggest that a multi-modal exercise intervention that includes motor as well as physical training and requires sustained attention and concentration, may better elicit the actual potency of exercise to enhance cognitive performance. This study will test the effect of a multi-modal exercise program, for older women, on cognitive and physical functioning. Methods/design. This randomised controlled trial involves community dwelling women, without cognitive impairment, aged 65-75 years. Participants are randomised to exercise intervention or non-exercise control groups, for 16 weeks. The intervention consists of twice weekly, 60 minute, exercise classes incorporating aerobic, strength, balance, flexibility, co-ordination and agility training. Primary outcomes are measures of cognitive function and secondary outcomes include physical functioning and a neurocognitive biomarker (brain derived neurotrophic factor). Measures are taken at baseline and 16 weeks later and qualitative data related to the experience and acceptability of the program are collected from a sub-sample of the intervention group. Discussion. If this randomised controlled trial demonstrates that multimodal exercise (that includes motor fitness training) can improve cognitive performance in later life, the benefits will be two-fold. First, an inexpensive, effective strategy will have been developed that could ameliorate the increased prevalence of age-related cognitive impairment predicted to accompany population ageing. Second, more robust evidence will have been provided about the mechanisms that link exercise to cognitive improvement allowing future research to be better focused and potentially more productive. Trial registration. Australian and New Zealand Clinical Trial Registration Number: ANZCTR12612000451808. © 2012 Vaughan et al.; licensee BioMed Central Ltd.
Original languageEnglish
Article number60
JournalBMC Geriatrics
Publication statusPublished - 28 Sept 2012
Externally publishedYes


  • Aged
  • Brain derived neurotrophic factor
  • Cognition
  • Exercise
  • Multi-modal exercise

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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