Structure-Element Surface Modification Strategy Enhances the Antibacterial Performance of Zr-BMGs

Cezhi Du, Yuhe Yang, Lijuan Zheng, Tao Zhang, Xin Zhao, Chengyong Wang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)

Abstract

Zirconium-based metallic glasses (Zr-BMGs) have attracted tremendous attention in healthcare fields, especially in the design of surgical tools and orthopedic implants, due to their unique amorphous structure; however, the application of Zr-BMG-based medical devices is hindered by bacterial contamination. Here, a structure-element strategy is proposed to improve the antibacterial performance of Zr-BMGs by surface laser nanostructuring and silver nanoparticle (AgNP) deposition. The laser nanostructuring process generates a disordered nanoparticle structure (NP) and laser-induced periodic surface structure (LIPSS) to decrease the surface bacterial adhesion and increase the internal antimicrobial ion release. Moreover, after Ag deposition and hydrogen peroxide (H2O2) treatment, the antibacterial adhesion ability of the Zr-BMG surface can be further improved without any influence on the crystallization of Zr-BMGs and the release of antibacterial copper/nickel (Cu/Ni). The antibacterial effect of the LIPSS and the NP surfaces presents over 90% bacterial killing ratio, which is superior to that of the naked Zr-BMGs with less than 60% bacterial killing ratio. In vitro and in vivo tests show that the Ag-deposited and H2O2-treated LIPSS surfaces exhibit an optimal balance between the antibacterial property and the biocompatibility compared with the polished, NP structured or LIPSS structured surfaces. It is assumed that such structure-element surface modification strategy can improve the antibacterial activity of metal-containing surgical tools and orthopedic implants, improving the success rate of medical treatment.

Original languageEnglish
Pages (from-to)8793-8803
Number of pages11
JournalACS Applied Materials and Interfaces
Volume14
Issue number7
DOIs
Publication statusPublished - 23 Feb 2022

Keywords

  • Antibacterial property
  • Laser nanostructuring
  • Metal ion release
  • Nanosilver deposition
  • Zirconium-based bulk metallic glass

ASJC Scopus subject areas

  • General Materials Science

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