Structure-Antibacterial Activity Relationships of Imidazolium-Type Ionic Liquid Monomers, Poly(ionic liquids) and Poly(ionic liquid) Membranes: Effect of Alkyl Chain Length and Cations

Zhiqiang Zheng, Qiming Xu, Jiangna Guo, Jing Qin, Hailei Mao, Bin Wang, Feng Yan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

110 Citations (Scopus)

Abstract

The structure-Antibacterial activity relationship between the small molecular compounds and polymers are still elusive. Here, imidazolium-type ionic liquid (IL) monomers and their corresponding poly(ionic liquids) (PILs) and poly(ionic liquid) membranes were synthesized. The effect of chemical structure, including carbon chain length of substitution at the N3 position and charge density of cations (mono- or bis-imidazolium) on the antimicrobial activities against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was investigated by determination of minimum inhibitory concentration (MIC). The antibacterial activities of both ILs and PILs were improved with the increase of the alkyl chain length and higher charge density (bis-cations) of imidazolium cations. Moreover, PILs exhibited lower MIC values relative to the IL monomers. However, the antibacterial activities of PIL membranes showed no correlation to those of their analogous small molecule IL monomers and PILs, which increased with the charge density (bis-cations) while decreasing with the increase of alkyl chain length. The results indicated that antibacterial property studies on small molecules and homopolymers may not provide a solid basis for evaluating that in corresponding polymer membranes.
Original languageEnglish
Pages (from-to)12684-12692
Number of pages9
JournalACS Applied Materials and Interfaces
Volume8
Issue number20
DOIs
Publication statusPublished - 25 May 2016
Externally publishedYes

Keywords

  • antibacterial
  • imidazolium cation
  • ionic liquid
  • membrane surface
  • poly(ionic liquid) membrane
  • structure-Activity relationship

ASJC Scopus subject areas

  • Materials Science(all)

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