Stretch-activated channels in muscular dystrophy

Wai Ella Yeung

Research output: Chapter in book / Conference proceedingChapter in an edited book (as author)Academic researchpeer-review

Abstract

Duchenne muscular dystrophy is a devastating genetic disease caused by the absence of the protein dystrophin. The pathogenic mechanisms are complex and there is currently no cure for the disease. Dystrophic muscles are susceptible to damage induced by muscle contractions, and excessive calcium influx is thought to trigger a pathological cascade of events that ultimately results in muscle fiber degeneration. Stretch-activated (or mechanosensitive) ion channels have been proposed to be implicated in the regulation of calcium entry in dystrophic muscle. Although the precise molecular nature of the channels is unclear, emerging evidence suggests that these channels are mediators of altered calcium homeostasis, causing muscle damage and progressive muscle weakness in muscular dystrophy.
Original languageEnglish
Title of host publicationSkeletal Muscle
Subtitle of host publicationPhysiology, Classification and Disease
PublisherNova Science Publishers, Inc.
Pages129-140
Number of pages12
ISBN (Print)9781624172717
Publication statusPublished - 1 Feb 2013

ASJC Scopus subject areas

  • Medicine(all)

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