Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum

Jianyong Wu, Chuangui Wang, Xingguo Mei

Research output: Journal article publicationJournal articleAcademic researchpeer-review

109 Citations (Scopus)


The trivalent ion of a rare earth element, lanthanum, was tested for elicitor-like effects on taxol production in suspension cultures of four different Taxus spp cells. In T. yunnanensis cell cultures, the lanthanum ion at concentrations from 1.15 to 23.0 μM stimulated taxol production. The lanthanum ion also promoted taxol excretion by the T. yunnanensis cells considerably. The maximum stimulation of taxol production was achieved by the addition of 5.8 μM La3+to the culture during mid-log growth phase, increasing the volumetric taxol yield by nearly threefold, from 2.61 ± 0.37 to 9.89 ± 1.92 mg l-1over a 28 day culture period. At higher concentrations, i.e. 23.1 and 46.2 μM, however, the lanthanum ion caused significant growth inhibition. For the other three Taxus cell lines, namely an embryo and a leave cell of T. chinensis and a stem cell of T. chinensis marv, the addition of lanthanum ion to the culture only had a significant effect on taxol production by the T. chinensis marv stem cells, increasing the volumetric yield by about threefold to 4.69 ± 0.76 mg l-1. These results suggest that lanthanum has elicitor-like effects on secondary metabolite synthesis of plant cell cultures.
Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalJournal of Biotechnology
Issue number1
Publication statusPublished - 23 Jan 2001


  • Elicitation
  • Lanthanum
  • Plant cell culture
  • Rare earth
  • Taxol

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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