(Matrix presented) Ruthenium porphyrins catalyze three-component coupling reaction of α-diazo esters with a series of N-benzylidene imines and alkenes to form functionalized pyrrolidines in excellent diastereoselectivities. The reaction proceeds via a reactive ruthenium-carbene intermediate and its subsequent reaction with imine to generate azomethine ylide, which reacts with alkenes via 1,3-diploar cycloaddition.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry