Stereoselective intramolecular carbene C-H insertion catalyzed by rhodium(III) porphyrin complexes

Vanessakar Yan Lo, Hung Yat Thu, Yu Man Chan, Tsz Lung Lam, Wing Yiu Yu, Chi Ming Che

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)

Abstract

Rhodium(III) porphyrin complexes [Rh(Por)Me] are catalytically active towards stereoselective intramolecular carbene C-H insertions of α-diazoacetamides to give cis-β-lactams or trans-γ-lactams in yields up to 99% with regioselectivities up to 100% and cis/trans ratios up to 83:17 for β-lactams.
Original languageEnglish
Pages (from-to)2753-2757
Number of pages5
JournalSynlett
Volume23
Issue number19
DOIs
Publication statusPublished - 22 Oct 2012

Keywords

  • carbene C-H insertion
  • intramolecular cyclization
  • lactams
  • rhodium porphyrin
  • stereoselectivity

ASJC Scopus subject areas

  • Organic Chemistry

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