TY - JOUR
T1 - Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing
AU - Yang, Yuhe
AU - Suo, Di
AU - Xu, Tianpeng
AU - Zhao, Shuai
AU - Xu, Xiaoxiao
AU - Bei, Ho Pan
AU - Wong, Kenneth Kak Yuen
AU - Li, Qibin
AU - Zheng, Zijian
AU - Li, Bin
AU - Zhao, Xin
N1 - Publisher Copyright:
© 2024 The Authors.
PY - 2024/8/14
Y1 - 2024/8/14
N2 - Current sprayable hydrogel masks lack the stepwise protection, cleansing, and nourishment of extensive wounds, leading to delayed healing with scarring. Here, we develop a sprayable biomimetic double wound mask (BDM) with rapid autophasing and hierarchical programming for scarless wound healing. The BDMs comprise hydrophobic poly (lactide-co- propylene glycol-co-lactide) dimethacrylate (PLD) as top layer and hydrophilic gelatin methacrylate (GelMA) hydrogel as bottom layer, enabling swift autophasing into bilayered structure. After photocrosslinking, BDMs rapidly solidify with strong interfacial bonding, robust tissue adhesion, and excellent joint adaptiveness. Upon implementation, the bottom GelMA layer could immediately release calcium ion for rapid hemostasis, while the top PLD layer could maintain a moist, breathable, and sterile environment. These traits synergistically suppress the inflammatory tumor necrosis factor-αpathway while coordinating the cyclic guanosine monophosphate/ protein kinase G-Wnt/calcium ion signaling pathways to nourish angiogenesis. Collectively, our BDMs with self-regulated construction of bilayered structure could hierarchically program the healing progression with transformative potential for scarless wound healing.
AB - Current sprayable hydrogel masks lack the stepwise protection, cleansing, and nourishment of extensive wounds, leading to delayed healing with scarring. Here, we develop a sprayable biomimetic double wound mask (BDM) with rapid autophasing and hierarchical programming for scarless wound healing. The BDMs comprise hydrophobic poly (lactide-co- propylene glycol-co-lactide) dimethacrylate (PLD) as top layer and hydrophilic gelatin methacrylate (GelMA) hydrogel as bottom layer, enabling swift autophasing into bilayered structure. After photocrosslinking, BDMs rapidly solidify with strong interfacial bonding, robust tissue adhesion, and excellent joint adaptiveness. Upon implementation, the bottom GelMA layer could immediately release calcium ion for rapid hemostasis, while the top PLD layer could maintain a moist, breathable, and sterile environment. These traits synergistically suppress the inflammatory tumor necrosis factor-αpathway while coordinating the cyclic guanosine monophosphate/ protein kinase G-Wnt/calcium ion signaling pathways to nourish angiogenesis. Collectively, our BDMs with self-regulated construction of bilayered structure could hierarchically program the healing progression with transformative potential for scarless wound healing.
UR - https://www.scopus.com/pages/publications/85201352160
U2 - 10.1126/sciadv.ado9479
DO - 10.1126/sciadv.ado9479
M3 - Journal article
C2 - 39141725
AN - SCOPUS:85201352160
SN - 2375-2548
VL - 10
JO - Science advances
JF - Science advances
IS - 33
M1 - ado9479
ER -