Sphinganine potentiation of dimethyl sulfoxide-induced granulocytic differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60)

Yat Ming Yung; Te Fang Hsiao; Lillian Li Lin Wei; Eric Ka Wai Hui

doi:10.1006/bbrc.1994.1312

Sphinganine potentiation of dimethyl sulfoxide-induced granulocytic differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60)

Yat Ming Yung, Te Fang Hsiao, Lillian Li Lin Wei, Eric Ka Wai Hui

Research output: Journal article publication › Journal article › Academic research › peer-review

11 Citations (Scopus)

Abstract

The differentiation of HL-60 promyelocytic cells toward mature granulocytic cells induced by dimethyl sulfoxide (DMSO) was accompanied by a quantitative similar increase in alkaline phosphatase (ALP) activity and decrease in protein kinase C (PKC) activity. The combination of DMSO and sphinganine (SP), a potent inhibitor of PKC, increased in parallel the percentage of mature cells and the ALP activity. The enhancement of DMSO-induced differentiation and the potentiation of the decrease of PKC activity by SP also seemed to correlate with each other. Our results indicate that both ALP and PKC may play a role in the DMSO-induced granulocytic differentiation. Inc.

Original language	English
Pages (from-to)	888-896
Number of pages	9
Journal	Biochemical and Biophysical Research Communications
Volume	199
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1994.1312
Publication status	Published - 1 Jan 1994
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Yung, Y. M., Hsiao, T. F., Wei, L. L. L., & Hui, E. K. W. (1994). Sphinganine potentiation of dimethyl sulfoxide-induced granulocytic differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). Biochemical and Biophysical Research Communications, 199(2), 888-896. https://doi.org/10.1006/bbrc.1994.1312

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title = "Sphinganine potentiation of dimethyl sulfoxide-induced granulocytic differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60)",

abstract = "The differentiation of HL-60 promyelocytic cells toward mature granulocytic cells induced by dimethyl sulfoxide (DMSO) was accompanied by a quantitative similar increase in alkaline phosphatase (ALP) activity and decrease in protein kinase C (PKC) activity. The combination of DMSO and sphinganine (SP), a potent inhibitor of PKC, increased in parallel the percentage of mature cells and the ALP activity. The enhancement of DMSO-induced differentiation and the potentiation of the decrease of PKC activity by SP also seemed to correlate with each other. Our results indicate that both ALP and PKC may play a role in the DMSO-induced granulocytic differentiation. Inc.",

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Yung, YM, Hsiao, TF, Wei, LLL & Hui, EKW 1994, 'Sphinganine potentiation of dimethyl sulfoxide-induced granulocytic differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60)', Biochemical and Biophysical Research Communications, vol. 199, no. 2, pp. 888-896. https://doi.org/10.1006/bbrc.1994.1312

Sphinganine potentiation of dimethyl sulfoxide-induced granulocytic differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). / Yung, Yat Ming; Hsiao, Te Fang; Wei, Lillian Li Lin et al.
In: Biochemical and Biophysical Research Communications, Vol. 199, No. 2, 01.01.1994, p. 888-896.

Research output: Journal article publication › Journal article › Academic research › peer-review

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T1 - Sphinganine potentiation of dimethyl sulfoxide-induced granulocytic differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60)

AU - Yung, Yat Ming

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AU - Hui, Eric Ka Wai

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AB - The differentiation of HL-60 promyelocytic cells toward mature granulocytic cells induced by dimethyl sulfoxide (DMSO) was accompanied by a quantitative similar increase in alkaline phosphatase (ALP) activity and decrease in protein kinase C (PKC) activity. The combination of DMSO and sphinganine (SP), a potent inhibitor of PKC, increased in parallel the percentage of mature cells and the ALP activity. The enhancement of DMSO-induced differentiation and the potentiation of the decrease of PKC activity by SP also seemed to correlate with each other. Our results indicate that both ALP and PKC may play a role in the DMSO-induced granulocytic differentiation. Inc.

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DO - 10.1006/bbrc.1994.1312

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VL - 199

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EP - 896

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Sphinganine potentiation of dimethyl sulfoxide-induced granulocytic differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60)

Abstract

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