Species variation in biology and physiology of the ciliary epithelium: Similarities and differences

Chi Wai Do, Mortimer M. Civan

Research output: Journal article publicationReview articleAcademic researchpeer-review

18 Citations (Scopus)

Abstract

Glaucoma is a leading cause of irreversible blindness worldwide. Lowering intraocular pressure (IOP) is the only strategy documented to delay the appearance and retard the progression of vision loss. One major approach for lowering IOP is to slow the rate of aqueous humor formation by the ciliary epithelium. As discussed in the present review, the transport basis for this secretion is largely understood. However, several substantive issues are yet to be resolved, including the integrated regulation of secretion, the functional topography of the ciliary epithelium, and the degree and significance of species variation in aqueous humor inflow. This review discusses species differences in net secretion, particularly of Cl- and HCO3- secretion. Identifying animal models most accurately mimicking aqueous humor formation in the human will facilitate development of future novel initiatives to lower IOP.
Original languageEnglish
Pages (from-to)631-640
Number of pages10
JournalExperimental Eye Research
Volume88
Issue number4
DOIs
Publication statusPublished - 30 Apr 2009

Keywords

  • aqueous humor
  • Cl secretion -
  • compartmentation of second messengers
  • HCO secretion 3 -
  • intraocular pressure
  • topography of ciliary epithelium

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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