Spatiotemporal dynamics of diffusional kurtosis, mean diffusivity and perfusion changes in experimental stroke

Edward S. Hui, Fang Du, Shiliang Huang, Qiang Shen, Timothy Q. Duong (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

74 Citations (Scopus)


Diffusional kurtosis imaging (DKI), which measures the non-Gaussianity of water diffusion, has been demonstrated to be a sensitive biomarker in many neuropathologies. The goal of this study was to longitudinally examine the spatiotemporal dynamics of DKI in cerebral ischemia in an animal model of permanent and transient (45 min) middle cerebral artery occlusion (MCAO) during the hyperacute, acute and chronic phases. Diffusional kurtosis showed different spatiotemporal dynamics. In particular, mean kurtosis (MK) was sensitive to hyperacute and acute stroke changes, and exhibited different contrast than mean diffusivity (MD) and higher contrast than fractional anisotropy (FA) and T2. MK contrast persisted 1 to 7 days post-occlusion, whereas MD showed renormalization at day 1-2 and reversed contrast at day 7. The current study showed that DKI has the potential to complement existing stroke imaging techniques, particularly in the assessment of subacute to early chronic stroke evolution.

Original languageEnglish
Pages (from-to)100-109
Number of pages10
JournalBrain Research
Publication statusPublished - 27 Apr 2012
Externally publishedYes


  • Cerebral ischemia
  • Diffusion
  • Diffusional kurtosis imaging
  • MCAO
  • Mean kurtosis
  • Perfusion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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