Spatiotemporal dual-delivery of therapeutic gas and growth factor for prevention of vascular stent thrombosis and restenosis

Qiufen Tu, Xin Zhao, Shuai Liu, Xiangyang Li, Qiang Zhang, Han Yu, Kaiqin Xiong, Nan Huang, Zhilu Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)

Abstract

Injury of endothelium is an inevitable consequence of cardiovascular stent implantation, which increases the incidence of in-stent restenosis (ISR) and late stent thrombosis (LST). Rapid and complete re-endothelialization, along with long-term suppression of smooth muscle cells (SMCs) are mandatory to alleviate these complications. To this goal, we designed a multi-functional stent coating, consisting of a vascular endothelial growth factor/CuII-dopamine(VEGF/CuII-DA) complex network for a spatiotemporal delivery of VEGF and nitric oxide (NO). We fabricated such network using a two-step stent-coating process: first a CuII-DA network with NO catalytic activity via metal-catecholamine coordination chemistry, followed by conjugation of VEGF onto the CuII-DA network via imine formation. The conjugated VEGF significantly accelerated the early-stage endothelial cell (EC) migration/growth for the first 7 days, forming a new and complete endothelial layer on the lumen. Furthermore, Cu ions sustainably decomposed endogenous S-nitrosothiols (RSNOs) in the bloodstream into NO for over 30 days, suppressing SMC migration/proliferation and ultimately preventing ISR and LST. Altogether, such designed stent coating provides options for a phase-adjusted endothelial repair during cardiovascular treatment.

Original languageEnglish
Article number100546
JournalApplied Materials Today
Volume19
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Biomimetic multi-functional coating
  • Cardiovascular stents
  • Nitric oxide
  • Spatiotemporal dual-delivery
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Materials Science(all)

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