Sonogenetics: Recent advances and future directions

Tianyi Liu; Mi Hyun Choi; Jiejun Zhu; Tingting Zhu; Jin Yang; Na Li; Zihao Chen; Quanxiang Xian; Xuandi Hou; Dongmin He; Jinghui Guo; Chunlong Fei; Lei Sun; Zhihai Qiu

doi:10.1016/j.brs.2022.09.002

Sonogenetics: Recent advances and future directions

Tianyi Liu, Mi Hyun Choi, Jiejun Zhu, Tingting Zhu, Jin Yang, Na Li, Zihao Chen, Quanxiang Xian, Xuandi Hou, Dongmin He, Jinghui Guo, Chunlong Fei, Lei Sun, Zhihai Qiu

Research output: Journal article publication › Review article › Academic research › peer-review

29 Citations (Scopus)

Abstract

Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.

Original language	English
Pages (from-to)	1308-1317
Number of pages	10
Journal	Brain Stimulation
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.brs.2022.09.002
Publication status	Published - 1 Sept 2022

ASJC Scopus subject areas

General Neuroscience
Biophysics
Clinical Neurology

More information

10.1016/j.brs.2022.09.002

http://hdl.handle.net/10397/98692

Cite this

@article{09ddc9941769412eb9c32d6288bb2883,

title = "Sonogenetics: Recent advances and future directions",

abstract = "Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.",

author = "Tianyi Liu and Choi, {Mi Hyun} and Jiejun Zhu and Tingting Zhu and Jin Yang and Na Li and Zihao Chen and Quanxiang Xian and Xuandi Hou and Dongmin He and Jinghui Guo and Chunlong Fei and Lei Sun and Zhihai Qiu",

note = "Funding Information: This work was supported by Special Fund for Science and Technology Innovation Strategy of Guangdong Province ( 2021B0909050004 ), The Hong Kong Research Grants Council General Research Fund ( 15104520 ), Hong Kong Innovation Technology Fund ( MHP/014/19 ), internal funding from the Hong Kong Polytechnic University Research Institute of Smart Ageing ( 1-CD76 ) and Hong Kong Polytechnic University ( 1-ZE1K , 1-BBAU , and 1-ZVW 8). Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = sep,

day = "1",

doi = "10.1016/j.brs.2022.09.002",

language = "English",

volume = "15",

pages = "1308--1317",

journal = "Brain Stimulation",

issn = "1935-861X",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Sonogenetics: Recent advances and future directions

AU - Liu, Tianyi

AU - Choi, Mi Hyun

AU - Zhu, Jiejun

AU - Zhu, Tingting

AU - Yang, Jin

AU - Li, Na

AU - Chen, Zihao

AU - Xian, Quanxiang

AU - Hou, Xuandi

AU - He, Dongmin

AU - Guo, Jinghui

AU - Fei, Chunlong

AU - Sun, Lei

AU - Qiu, Zhihai

N1 - Funding Information: This work was supported by Special Fund for Science and Technology Innovation Strategy of Guangdong Province ( 2021B0909050004 ), The Hong Kong Research Grants Council General Research Fund ( 15104520 ), Hong Kong Innovation Technology Fund ( MHP/014/19 ), internal funding from the Hong Kong Polytechnic University Research Institute of Smart Ageing ( 1-CD76 ) and Hong Kong Polytechnic University ( 1-ZE1K , 1-BBAU , and 1-ZVW 8). Publisher Copyright: © 2022 The Authors

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.

AB - Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.

UR - http://www.scopus.com/inward/record.url?scp=85138470582&partnerID=8YFLogxK

U2 - 10.1016/j.brs.2022.09.002

DO - 10.1016/j.brs.2022.09.002

M3 - Review article

C2 - 36130679

AN - SCOPUS:85138470582

SN - 1935-861X

VL - 15

SP - 1308

EP - 1317

JO - Brain Stimulation

JF - Brain Stimulation

IS - 5

ER -

Sonogenetics: Recent advances and future directions

Abstract

ASJC Scopus subject areas

More information

Other files and links

Fingerprint

Cite this