Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging

Kannie Wai Yan Chan, Wing Tak Wong

Research output: Journal article publicationReview articleAcademic researchpeer-review

150 Citations (Scopus)

Abstract

Magnetic resonance imaging (MRI) contrast agents that contain the gadolinium ion are widely used in biomedical research and diagnosis. The relaxation mechanism of these T1-agents highlights their sensitivity towards the proximal environment. Greater knowledge of the structurally related relaxation mechanism, particularly factors that govern relaxivity, leads to scrutinized chelate designs that improve contrast enhancement. Cyclic and acyclic polyaminocarboxylate gadolinium complexes, especially those have favourable water exchange and tumbling rate for relaxation, have been reported to improve relaxivity and specificity. The criteria for a large relaxivity gain upon protein binding, such as the human serum albumin (HSA), are elucidated through the relaxometric study of the protein-chelate adduct. This adduct is an important model for the development of contrast agents, which may allow the in vivo visualization of proteins. The strength of HSA binding and the observed relaxivity are related to the pharmacokinetic profile of the contrast agents and give insight in the sensitivity of the agents after intravenous administration. By using animal models, an understanding of the physiology of contrast agents, including their biodistribution, excretion, and possible site of interaction, is acquired. The in vitro studies of contrast agents have demonstrated the feasibility of imaging various disease-related proteins, cell types, and gene delivery and expression. Imaging at the molecular level can be achieved through this integrative approach and the incorporation of nanotechnology in drug delivery.
Original languageEnglish
Pages (from-to)2428-2451
Number of pages24
JournalCoordination Chemistry Reviews
Volume251
Issue number17-20
DOIs
Publication statusPublished - 1 Sep 2007
Externally publishedYes

Keywords

  • Gadolinium(III) complexes
  • Molecular imaging
  • MRI contrast agents
  • Polyaminocarboxylates
  • Protein probes

ASJC Scopus subject areas

  • Chemistry(all)

Cite this