Slug-flow microextraction coupled with paper spray mass spectrometry for rapid analysis of complex samples

Jiewei Deng, Wenwen Wang, Yunyun Yang, Xiaowei Wang, Baowei Chen, Zhongping Yao, Tiangang Luan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

21 Citations (Scopus)


Analysis of trace compounds in small-volume complex samples is of importance for forensic, clinical, pharmaceutical, environmental, and life science investigation. In this study, we reported the coupling of slug-flow microextraction with paper spray mass spectrometry for rapid analysis of trace analytes in small volume of complicated biological samples such as whole blood, milk, and body fluid, etc. The method is performed by applying a disposable glass capillary for rapid extraction of a small amount of complex samples using a small amount of organic solvent; the loaded organic solvent was then spotted onto a paper triangle and dried out; subsequently, a high voltage and some spray solvent were applied onto the paper triangle for mass spectrometric analysis. By using the proposed method, high sensitivity and satisfactory precision for quantitative analysis of trace macrolide antibiotics in whole bloods and milks as well as perfluorinated compounds in individual small organisms have been successfully achieved. In addition, investigation of bioaccumulation of perfluorinated compounds in individual small organisms has been reached.
Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalAnalytica Chimica Acta
Publication statusPublished - 12 Oct 2016


  • Macrolide antibiotics
  • Mass spectrometry
  • Paper spray
  • Perfluorinated compounds
  • Slug-flow microextraction

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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