TY - JOUR
T1 - Sleep disruption and its contributing factors in Chinese survivors of childhood cancer
T2 - A cross-sectional study
AU - Ho, K. Y.
AU - Lam, Katherine K.W.
AU - Xia, W.
AU - Chiu, S. Y.
AU - Chan, Godfrey C.F.
N1 - Funding Information:
We thank the survivors and their parents for spending their time in this study. We also thank Benjamin Knight, MSc., from Edanz ( https://www.edanz.com/ac ) for editing a draft of this manuscript. This study was supported by Seed Fund for Basic Research for New Staff (Ref: 201805159003), the University of Hong Kong, HKSAR.
Publisher Copyright:
© 2022 John Wiley & Sons Ltd.
PY - 2022
Y1 - 2022
N2 - Objectives: This study provided information about sleep disruption, particularly its prevalence and severity among Hong Kong Chinese childhood cancer survivors. Additionally, we identified the factors influencing sleep disruption and explored how fatigue, depressive symptoms and physical activity (PA) affect sleep disruption. Methods: Four hundred two survivors 6–18 years old and 50 age- and gender-matched healthy counterparts were assessed for depressive symptoms, fatigue, PA and subjective sleep quality. Demographic and clinical information were collected. Multiple logistic regression analyses were conducted to identify any factors contributing to poor sleep. Results: Mean scores of depressive symptoms, fatigue for children and that for adolescents, and PA in survivors were 16.1 (SD = 11.1), 24.6 (SD = 10.3), 27.7 (SD = 7.8), and 3.08 (SD = 2.9), respectively. 44.8% of the survivors were poor sleepers, which was more that in healthy counterparts. The three most common sleep problem were prolonged sleep latency (31.9%), daytime dysfunction (23.4%), and sleep disturbance (22.9%). The time since last treatment (children: AOR = 0.54, 95% CI = 0.30–0.96, p = 0.04; adolescents: AOR = 0.80, 95% CI = 0.70–0.92, p < 0.01) and PA levels (children: AOR = 0.46, 95% CI = 0.260–0.82, p = 0.01; adolescents: AOR = 0.70, 95% CI = 0.49–0.98, p = 0.04) were negatively associated with sleep disruption, while depressive symptoms (children: AOR = 1.31, 95% CI = 1.04–1.64, p = 0.02; adolescents: AOR = 1.07, 95% CI = 1.01–1.13, p = 0.03), fatigue (children: AOR = 1.15, 95% CI = 1.00–1.31, p = 0.04; adolescents: AOR = 1.08, 95% CI = 1.02–1.15, p = 0.01), number of treatment received (children: AOR = 16.56, 95% CI = 1.27–216.82, p = 0.03; adolescents: AOR = 7.30, 95% CI = 2.36–22.56, p < 0.01), and co-sleeping (children: AOR = 29.19, 95% CI = 1.65–511.57, p = 0.02; adolescents: AOR = 4.63, 95% CI = 1.22–17.61, p = 0.02) were positively associated with sleep disruption. Conclusion: Physical activity made the largest contribution to reduce sleep disruption. It is crucial to advocate for the adoption and maintenance of PA in survivorship.
AB - Objectives: This study provided information about sleep disruption, particularly its prevalence and severity among Hong Kong Chinese childhood cancer survivors. Additionally, we identified the factors influencing sleep disruption and explored how fatigue, depressive symptoms and physical activity (PA) affect sleep disruption. Methods: Four hundred two survivors 6–18 years old and 50 age- and gender-matched healthy counterparts were assessed for depressive symptoms, fatigue, PA and subjective sleep quality. Demographic and clinical information were collected. Multiple logistic regression analyses were conducted to identify any factors contributing to poor sleep. Results: Mean scores of depressive symptoms, fatigue for children and that for adolescents, and PA in survivors were 16.1 (SD = 11.1), 24.6 (SD = 10.3), 27.7 (SD = 7.8), and 3.08 (SD = 2.9), respectively. 44.8% of the survivors were poor sleepers, which was more that in healthy counterparts. The three most common sleep problem were prolonged sleep latency (31.9%), daytime dysfunction (23.4%), and sleep disturbance (22.9%). The time since last treatment (children: AOR = 0.54, 95% CI = 0.30–0.96, p = 0.04; adolescents: AOR = 0.80, 95% CI = 0.70–0.92, p < 0.01) and PA levels (children: AOR = 0.46, 95% CI = 0.260–0.82, p = 0.01; adolescents: AOR = 0.70, 95% CI = 0.49–0.98, p = 0.04) were negatively associated with sleep disruption, while depressive symptoms (children: AOR = 1.31, 95% CI = 1.04–1.64, p = 0.02; adolescents: AOR = 1.07, 95% CI = 1.01–1.13, p = 0.03), fatigue (children: AOR = 1.15, 95% CI = 1.00–1.31, p = 0.04; adolescents: AOR = 1.08, 95% CI = 1.02–1.15, p = 0.01), number of treatment received (children: AOR = 16.56, 95% CI = 1.27–216.82, p = 0.03; adolescents: AOR = 7.30, 95% CI = 2.36–22.56, p < 0.01), and co-sleeping (children: AOR = 29.19, 95% CI = 1.65–511.57, p = 0.02; adolescents: AOR = 4.63, 95% CI = 1.22–17.61, p = 0.02) were positively associated with sleep disruption. Conclusion: Physical activity made the largest contribution to reduce sleep disruption. It is crucial to advocate for the adoption and maintenance of PA in survivorship.
UR - http://www.scopus.com/inward/record.url?scp=85123793728&partnerID=8YFLogxK
U2 - 10.1002/pon.5884
DO - 10.1002/pon.5884
M3 - Journal article
C2 - 35072308
AN - SCOPUS:85123793728
SN - 1057-9249
JO - Psycho-Oncology
JF - Psycho-Oncology
ER -
