Single-shot ultrasound-modulated optical tomography with enhanced speckle contrast

Dean Yuan, Jiawei Luo, Daixuan Wu, Runsen Zhang, Puxiang Lai (Corresponding Author), Zhaohui Li, Yuecheng Shen (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

3 Citations (Scopus)


Ultrasound-modulated optical tomography (UOT) images optical contrast deep inside biological tissue. Among existing approaches, camera-based parallel detection is beneficial in modulation depth but is limited to the relatively slow framerate of cameras. This condition prevents such a scheme from achieving maturity to image live animals with submillisecond speckle correlation time. In this work, we developed on-axis single-shot UOT by investigating the statistics of speckles, breaking the restriction imposed by the slowcamera framerate. As a proof of concept,we experimentally imaged a one-dimensional absorptive object buried inside a moving scattering medium with speckle correlation time down to 0.48 ms. We envision that this single-shot UOT is promising to cope with live animals with fast speckle decorrelation.

Original languageEnglish
Pages (from-to)3095-3098
Number of pages4
JournalOptics Letters
Issue number13
Publication statusPublished - 1 Jul 2021

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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