Single living cell refractometry using FBG-based resonant cavity

L. K. Chin; C. S. Lim; P. H. Yap; J. H. Ng; J. Z. Hao; S. Takahashi; A. Q. Liu

doi:10.1109/SENSOR.2007.4300264

Single living cell refractometry using FBG-based resonant cavity

L. K. Chin, C. S. Lim, P. H. Yap, J. H. Ng, J. Z. Hao, S. Takahashi, A. Q. Liu

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

3 Citations (Scopus)

Abstract

This paper reports a single cell refractometer consists of FBG fiber-based resonant cavity by employing buffer modulation method. In this biophotonic chip, single cell is trapped optically in the cavity, and the transmission spectral shifts due to the change of surrounding buffer, without and with cell, are used to determine the cell's refractive index (RI) and size. The measurement shows that MDCK cell has an effective RI of 1.383 at a precision of 0.1%. Moreover, the measurement method with optical trapping eliminates uncertain factors and prevents cell damage. The chip is promising for label-free cell measurement and further cell analysis.

Original language	English
Title of host publication	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	851-854
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2007.4300264
Publication status	Published - Jun 2007
Externally published	Yes
Event	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 - Lyon, France Duration: 10 Jun 2007 → 14 Jun 2007

Publication series

Name	TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems

Conference

Conference	4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
Country/Territory	France
City	Lyon
Period	10/06/07 → 14/06/07

Keywords

Buffer modulation and refractive index
Fiber bragg gratings
Single cell measurement

ASJC Scopus subject areas

Control and Systems Engineering
Electrical and Electronic Engineering

More information

10.1109/SENSOR.2007.4300264

Cite this

Chin, L. K., Lim, C. S., Yap, P. H., Ng, J. H., Hao, J. Z., Takahashi, S., & Liu, A. Q. (2007). Single living cell refractometry using FBG-based resonant cavity. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 851-854). Article 4300264 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2007.4300264

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title = "Single living cell refractometry using FBG-based resonant cavity",

abstract = "This paper reports a single cell refractometer consists of FBG fiber-based resonant cavity by employing buffer modulation method. In this biophotonic chip, single cell is trapped optically in the cavity, and the transmission spectral shifts due to the change of surrounding buffer, without and with cell, are used to determine the cell's refractive index (RI) and size. The measurement shows that MDCK cell has an effective RI of 1.383 at a precision of 0.1%. Moreover, the measurement method with optical trapping eliminates uncertain factors and prevents cell damage. The chip is promising for label-free cell measurement and further cell analysis.",

keywords = "Buffer modulation and refractive index, Fiber bragg gratings, Single cell measurement",

author = "Chin, {L. K.} and Lim, {C. S.} and Yap, {P. H.} and Ng, {J. H.} and Hao, {J. Z.} and S. Takahashi and Liu, {A. Q.}",

year = "2007",

month = jun,

doi = "10.1109/SENSOR.2007.4300264",

language = "English",

isbn = "1424408423",

series = "TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems",

pages = "851--854",

booktitle = "TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems",

note = "4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 ; Conference date: 10-06-2007 Through 14-06-2007",

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Chin, LK, Lim, CS, Yap, PH, Ng, JH, Hao, JZ, Takahashi, S & Liu, AQ 2007, Single living cell refractometry using FBG-based resonant cavity. in TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems., 4300264, TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 851-854, 4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07, Lyon, France, 10/06/07. https://doi.org/10.1109/SENSOR.2007.4300264

Single living cell refractometry using FBG-based resonant cavity. / Chin, L. K.; Lim, C. S.; Yap, P. H. et al.
TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 851-854 4300264 (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

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AU - Lim, C. S.

AU - Yap, P. H.

AU - Ng, J. H.

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AU - Takahashi, S.

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AB - This paper reports a single cell refractometer consists of FBG fiber-based resonant cavity by employing buffer modulation method. In this biophotonic chip, single cell is trapped optically in the cavity, and the transmission spectral shifts due to the change of surrounding buffer, without and with cell, are used to determine the cell's refractive index (RI) and size. The measurement shows that MDCK cell has an effective RI of 1.383 at a precision of 0.1%. Moreover, the measurement method with optical trapping eliminates uncertain factors and prevents cell damage. The chip is promising for label-free cell measurement and further cell analysis.

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Chin LK, Lim CS, Yap PH, Ng JH, Hao JZ, Takahashi S et al. Single living cell refractometry using FBG-based resonant cavity. In TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems. 2007. p. 851-854. 4300264. (TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2007.4300264

Single living cell refractometry using FBG-based resonant cavity

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