Single living cell manipulation and microrheological study with laser-induced cavitation bubbles

Z. G. Li, P. A. Quinto-Su, J. B. Zhang, C. D. Ohl, A. Q. Liu

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

In this paper, a new method for measuring the pure mechanical responses of single living cells is proposed using laser-induced cavitation bubbles. An optical system with a high speed Charge Coupled Device (CCD) camera is built to generate cavitation bubbles in a chamber with sample fluid and capture the ultra fast process of the deformation of the living cells. A Madin-Darby canine kidney (MDCK) in cochineal color food dye solution is squeezed by the pressure field generated by a pair of cavitation bubbles and the deformation process is recorded and analyzed. This method has great potential applications in cell manipulations and measurement of rheological response of single living cell.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages1658-1660
Number of pages3
Publication statusPublished - Oct 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 3 Oct 20107 Oct 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Conference

Conference14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period3/10/107/10/10

Keywords

  • Laser-induced cavitation bubbles
  • Microdroplet
  • Microrheological study
  • Single living cell

ASJC Scopus subject areas

  • Control and Systems Engineering

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