TY - JOUR
T1 - Simultaneous electrochemical sensing of serotonin, dopamine and ascorbic acid by using a nanocomposite prepared from reduced graphene oxide, Fe3O4 and hydroxypropyl-β-cyclodextrin
AU - Liang, Wenting
AU - Rong, Yanqin
AU - Fan, Lifang
AU - Zhang, Caihong
AU - Dong, Wenjuan
AU - Li, Jing
AU - Niu, Jianping
AU - Yang, Cheng
AU - Shuang, Shaomin
AU - Dong, Chuan
AU - Wong, Wai Yeung
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Reduced graphene oxide containing Fe3O4 nanoparticles was decorated with hydroxypropyl-β-cyclodextrin (HP-β-CD) to construct a novel nanocomposite (3D-rGO/Fe3O4/HP-β-CD). The composite was placed on a glassy carbon electrode (GCE) to design an electrochemical sensor for detecting simultaneously serotonin (5-HT), dopamine (DA), and ascorbic acid (AA). The interconnected porous reduced graphene oxide framework tightly anchored to the Fe3O4 magnetic nanoparticles warrants good electrical conductivity and efficient catalytic activity. The HP-β-CD acts as a supramolecular host with high recognition ability for 5-HT, DA and AA. Well-separated oxidation peaks and increased peak currents were observed for 5-HT, DA, and AA individually and in mixtures by differential pulse voltammetry (DPV). The following figures of merit were found for simultaneous electrochemical determination of 5-HT, DA, and AA: (a) Well separated peaks at around 0.316, 0.16 and − 0.044 V; (b) linear responses in the 0.01 – 25 μM, 0.02 – 25 μM and 10 – 350 μM; (c) detection limits of 3.3 nM, 6.7 nM and 3.3 μM (S/N = 3), and (d) recoveries of 96.9-103%, 97.3%-102% and 96.3-105% from spiked serum samples, respectively. All relative standard deviation (RSD) are less than 4%. [Figure not available: see fulltext.].
AB - Reduced graphene oxide containing Fe3O4 nanoparticles was decorated with hydroxypropyl-β-cyclodextrin (HP-β-CD) to construct a novel nanocomposite (3D-rGO/Fe3O4/HP-β-CD). The composite was placed on a glassy carbon electrode (GCE) to design an electrochemical sensor for detecting simultaneously serotonin (5-HT), dopamine (DA), and ascorbic acid (AA). The interconnected porous reduced graphene oxide framework tightly anchored to the Fe3O4 magnetic nanoparticles warrants good electrical conductivity and efficient catalytic activity. The HP-β-CD acts as a supramolecular host with high recognition ability for 5-HT, DA and AA. Well-separated oxidation peaks and increased peak currents were observed for 5-HT, DA, and AA individually and in mixtures by differential pulse voltammetry (DPV). The following figures of merit were found for simultaneous electrochemical determination of 5-HT, DA, and AA: (a) Well separated peaks at around 0.316, 0.16 and − 0.044 V; (b) linear responses in the 0.01 – 25 μM, 0.02 – 25 μM and 10 – 350 μM; (c) detection limits of 3.3 nM, 6.7 nM and 3.3 μM (S/N = 3), and (d) recoveries of 96.9-103%, 97.3%-102% and 96.3-105% from spiked serum samples, respectively. All relative standard deviation (RSD) are less than 4%. [Figure not available: see fulltext.].
KW - Electrochemical sensing platform
KW - Hydroxypropyl-β-cyclodextrin
KW - Magnetic nanoparticles
KW - Simultaneous determination
KW - Three-dimensional reduced-graphene oxide
UR - http://www.scopus.com/inward/record.url?scp=85074690452&partnerID=8YFLogxK
U2 - 10.1007/s00604-019-3861-3
DO - 10.1007/s00604-019-3861-3
M3 - Journal article
C2 - 31701250
AN - SCOPUS:85074690452
VL - 186
JO - Mikrochimica Acta
JF - Mikrochimica Acta
SN - 0026-3672
IS - 12
M1 - 751
ER -