Simultaneous electrochemical sensing of serotonin, dopamine and ascorbic acid by using a nanocomposite prepared from reduced graphene oxide, Fe3O4 and hydroxypropyl-β-cyclodextrin

Wenting Liang, Yanqin Rong, Lifang Fan, Caihong Zhang, Wenjuan Dong, Jing Li, Jianping Niu, Cheng Yang, Shaomin Shuang, Chuan Dong, Wai Yeung Wong (Corresponding Author)

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Reduced graphene oxide containing Fe3O4 nanoparticles was decorated with hydroxypropyl-β-cyclodextrin (HP-β-CD) to construct a novel nanocomposite (3D-rGO/Fe3O4/HP-β-CD). The composite was placed on a glassy carbon electrode (GCE) to design an electrochemical sensor for detecting simultaneously serotonin (5-HT), dopamine (DA), and ascorbic acid (AA). The interconnected porous reduced graphene oxide framework tightly anchored to the Fe3O4 magnetic nanoparticles warrants good electrical conductivity and efficient catalytic activity. The HP-β-CD acts as a supramolecular host with high recognition ability for 5-HT, DA and AA. Well-separated oxidation peaks and increased peak currents were observed for 5-HT, DA, and AA individually and in mixtures by differential pulse voltammetry (DPV). The following figures of merit were found for simultaneous electrochemical determination of 5-HT, DA, and AA: (a) Well separated peaks at around 0.316, 0.16 and − 0.044 V; (b) linear responses in the 0.01 – 25 μM, 0.02 – 25 μM and 10 – 350 μM; (c) detection limits of 3.3 nM, 6.7 nM and 3.3 μM (S/N = 3), and (d) recoveries of 96.9-103%, 97.3%-102% and 96.3-105% from spiked serum samples, respectively. All relative standard deviation (RSD) are less than 4%. [Figure not available: see fulltext.].

Original languageEnglish
Article number751
JournalMicrochimica Acta
Issue number12
Publication statusPublished - 1 Dec 2019


  • Electrochemical sensing platform
  • Hydroxypropyl-β-cyclodextrin
  • Magnetic nanoparticles
  • Simultaneous determination
  • Three-dimensional reduced-graphene oxide

ASJC Scopus subject areas

  • Analytical Chemistry

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