TY - GEN
T1 - Simulating the Dynamics of Primary Cilium in Pulsatile Flow by the Immersed Boundary-Lattice Boltzmann Method
AU - Cui, Jingyu
AU - Liu, Yang
AU - Lanlan, Xiao
AU - Shuo, Chen
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
PY - 2021/5
Y1 - 2021/5
N2 - In this study, the dynamics of primary cilium (PC) in a pulsatile blood flow is numerically studied. The two-way fluid-cilium interaction is handled by an explicit immersed boundary-lattice Boltzmann method with the cilium base being modeled as a nonlinear rotational spring (Resnick in Biophys J 109:18–25, 2015 [1]). The fluid-cilium interaction system is investigated at several pulsatile flow cases, which are obtained by varying the flow peak Reynolds numbers (Repeak ) and Womersley numbers (Wo ). The cilium’s dynamics is observed to be closely related to the Repeak and Wo. Increasing the Repeak or decreasing the Wo results in an increase in cilium’s flapping amplitude, tip angular speed and maximum tensile stress. We also demonstrated that by reducing the Repeak or enhancing the Wo, one can shift the two-side flapping pattern of PC to a one-side one, making the stretch only occurs on one side. During the flapping process, the location of the maximum tensile stress is not always found at the basal region, instead, it is able to propagate from time to time within a certain distance to the base.
AB - In this study, the dynamics of primary cilium (PC) in a pulsatile blood flow is numerically studied. The two-way fluid-cilium interaction is handled by an explicit immersed boundary-lattice Boltzmann method with the cilium base being modeled as a nonlinear rotational spring (Resnick in Biophys J 109:18–25, 2015 [1]). The fluid-cilium interaction system is investigated at several pulsatile flow cases, which are obtained by varying the flow peak Reynolds numbers (Repeak ) and Womersley numbers (Wo ). The cilium’s dynamics is observed to be closely related to the Repeak and Wo. Increasing the Repeak or decreasing the Wo results in an increase in cilium’s flapping amplitude, tip angular speed and maximum tensile stress. We also demonstrated that by reducing the Repeak or enhancing the Wo, one can shift the two-side flapping pattern of PC to a one-side one, making the stretch only occurs on one side. During the flapping process, the location of the maximum tensile stress is not always found at the basal region, instead, it is able to propagate from time to time within a certain distance to the base.
KW - Cilium dynamics
KW - Fluid–structure interaction
KW - Immersed boundary-lattice Boltzmann method
KW - Pulsatile flow
UR - http://www.scopus.com/inward/record.url?scp=85106437191&partnerID=8YFLogxK
U2 - 10.1007/978-981-33-4960-5_1
DO - 10.1007/978-981-33-4960-5_1
M3 - Conference article published in proceeding or book
AN - SCOPUS:85106437191
SN - 9789813349599
T3 - Lecture Notes in Mechanical Engineering
SP - 1
EP - 7
BT - Fluid-Structure-Sound Interactions and Control - Proceedings of the 5th Symposium on Fluid-Structure-Sound Interactions and Control
A2 - Braza, Marianna
A2 - Hoarau, Yannick
A2 - Zhou, Yu
A2 - Lucey, Anthony D.
A2 - Huang, Lixi
A2 - Stavroulakis, Georgios E.
PB - Springer Science and Business Media Deutschland GmbH
T2 - 5th Symposium on Fluid-Structure-Sound Interactions and Control, FSSIC 2019
Y2 - 27 August 2019 through 30 August 2019
ER -