Simulating the Dynamics of Primary Cilium in Pulsatile Flow by the Immersed Boundary-Lattice Boltzmann Method

Jingyu Cui, Yang Liu, Xiao Lanlan, Chen Shuo

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

In this study, the dynamics of primary cilium (PC) in a pulsatile blood flow is numerically studied. The two-way fluid-cilium interaction is handled by an explicit immersed boundary-lattice Boltzmann method with the cilium base being modeled as a nonlinear rotational spring (Resnick in Biophys J 109:18–25, 2015 [1]). The fluid-cilium interaction system is investigated at several pulsatile flow cases, which are obtained by varying the flow peak Reynolds numbers (Repeak ) and Womersley numbers (Wo ). The cilium’s dynamics is observed to be closely related to the Repeak and Wo. Increasing the Repeak or decreasing the Wo results in an increase in cilium’s flapping amplitude, tip angular speed and maximum tensile stress. We also demonstrated that by reducing the Repeak or enhancing the Wo, one can shift the two-side flapping pattern of PC to a one-side one, making the stretch only occurs on one side. During the flapping process, the location of the maximum tensile stress is not always found at the basal region, instead, it is able to propagate from time to time within a certain distance to the base.

Original languageEnglish
Title of host publicationFluid-Structure-Sound Interactions and Control - Proceedings of the 5th Symposium on Fluid-Structure-Sound Interactions and Control
EditorsMarianna Braza, Yannick Hoarau, Yu Zhou, Anthony D. Lucey, Lixi Huang, Georgios E. Stavroulakis
PublisherSpringer Science and Business Media Deutschland GmbH
Pages1-7
Number of pages7
ISBN (Print)9789813349599
DOIs
Publication statusPublished - 2021
Event5th Symposium on Fluid-Structure-Sound Interactions and Control, FSSIC 2019 - Chania, Greece
Duration: 27 Aug 201930 Aug 2019

Publication series

NameLecture Notes in Mechanical Engineering
ISSN (Print)2195-4356
ISSN (Electronic)2195-4364

Conference

Conference5th Symposium on Fluid-Structure-Sound Interactions and Control, FSSIC 2019
Country/TerritoryGreece
CityChania
Period27/08/1930/08/19

Keywords

  • Cilium dynamics
  • Fluid–structure interaction
  • Immersed boundary-lattice Boltzmann method
  • Pulsatile flow

ASJC Scopus subject areas

  • Automotive Engineering
  • Aerospace Engineering
  • Mechanical Engineering
  • Fluid Flow and Transfer Processes

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