Similarity of markers identified from cancer gene expression studies: Observations from GEO

Xingjie Shi, Shihao Shen, Jin Liu, Jian Huang, Yong Zhou, Shuangge Ma

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

Gene expression profiling has been extensively conducted in cancer research. The analysis of multiple independent cancer gene expression datasets may provide additional information and complement single-dataset analysis. In this study, we conduct multi-dataset analysis and are interested in evaluating the similarity of cancer-associated genes identified from different datasets. The first objective of this study is to briefly review some statistical methods that can be used for such evaluation. Both marginal analysis and joint analysis methods are reviewed. The second objective is to apply those methods to 26 Gene Expression Omnibus (GEO) datasets on five types of cancers.Our analysis suggests that for the same cancer, the marker identification results may vary significantly across datasets, and different datasets share few common genes. In addition, datasets on different cancers share few common genes. The shared genetic basis of datasets on the same or different cancers, which has been suggested in the literature, is not observed in the analysis of GEO data.
Original languageEnglish
Pages (from-to)671-684
Number of pages14
JournalBriefings in Bioinformatics
Volume15
Issue number5
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Keywords

  • Cancer gene expression study
  • GEO
  • Marker identification
  • Similarity

ASJC Scopus subject areas

  • Information Systems
  • Molecular Biology

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