Silver nanoparticles/ibuprofen-loaded poly(L-lactide) fibrous membrane: Anti-infection and anti-adhesion effects

Shuai Chen, Guangda Wang, Tianyi Wu, Xin Zhao, Shen Liu, Gang Li, Wenguo Cui, Cunyi Fan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

24 Citations (Scopus)

Abstract

Infection caused by bacteria is one of the crucial risk factors for tendon adhesion formation. Silver nanoparticles (AgNP)-loaded physical barriers were reported to be effective in anti-infection and anti-adhesion. However, high silver load may lead to kidney and liver damages. This study was designed for Ibuprofen (IBU)-loaded poly(l-lactide) (PLLA) electrospun fibrous membranes containing a low dosage of Ag to evaluate its potential in maintaining suitable anti-infection and good anti-adhesion effects. The in vitro drug release study showed a sustained release of Ag ions and IBU from the membrane. Inferior adherence and proliferation of fibroblasts were found on the Ag4%-IBU4%-loaded PLLA electrospun fibrous membranes in comparison with pure PLLA and 4% Ag-loaded PLLA membranes. In the antibacterial test, all Ag-loaded PLLA electrospun fibrous membranes prevented the adhesion of Staphylococcus aureus and Staphylococcus epidermidis. Taken together, these results demonstrate that Ibuprofen is effective in enhancing the anti-adhesion and anti-proliferation effects of 4% Ag-loaded PLLA fibrous membrane. The medical potential of infection reduction and adhesion prevention of Ag4%-IBU4%-loaded PLLA electrospun fibrous membrane deserves to be further studied.
Original languageEnglish
Pages (from-to)14014-14025
Number of pages12
JournalInternational Journal of Molecular Sciences
Volume15
Issue number8
DOIs
Publication statusPublished - 11 Aug 2014
Externally publishedYes

Keywords

  • Antimicrobial polymers
  • Electrospun membrane
  • Ibuprofen
  • Peritendinous adhesions
  • Silver nanoparticle

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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