@article{f2b2048ab8d348369bc7763c787f44ae,
title = "Silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides with anilines and phenols",
abstract = "A simple and efficient method for the silver-catalyzed regioselective 1,6-hydroarylation of para-quinone methides (p-QMs) with anilines and phenols has been established. Without the need for pre-protection, a broad range of anilines (primary amine, secondary amine and tertiary amine), phenols and para-quinone methides are well tolerated under mild conditions, giving the corresponding 1,6-hydroarylation products with moderate to good yields. Moreover, a series of modified natural products can be synthesized via this simple method. Control experiments were also performed to gain insights into the plausible reaction mechanism. This protocol has high atom economy, and may have significant implications for the formation of C(sp3)-C(sp2) bonds in organic synthesis.",
author = "Biquan Xiong and Shipan Xu and Weifeng Xu and Yu Liu and Limin Zhang and Tang, {Ke Wen} and Yin, {Shuang Feng} and Wong, {Wai Yeung}",
note = "Funding Information: This work was supported by the National Natural Science Foundation of China (21606080, 21725602, and 21908050), Natural Science Foundation of Hunan Province (2019JJ50203), Scientific Research Fund of the Hunan Provincial Education Department (19A197), and Innovation Research Group Project of the Natural Science Foundation of Hunan Province (No. 2020JJ1004). W.-Y. W. thanks the CAS-Croucher Funding Scheme for Joint Laboratories, ITC Guangdong-Hong Kong Technology Cooperation Funding Scheme (TCFS) (GHP/038/19GD), the RGC Senior Research Fellowship Scheme (SRFS 2021-5S01), the Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices (2019B121205001), Hong Kong Polytechnic University (1-ZE1C), Research Institute for Smart Energy (RISE) and the Endowed Professorship in Energy from Miss Clarea Au (847S) for financial support. Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",
year = "2022",
month = may,
day = "24",
doi = "10.1039/d2qo00541g",
language = "English",
volume = "9",
pages = "3807--3817",
journal = "Organic Chemistry Frontiers",
issn = "2052-4110",
publisher = "Royal Society of Chemistry",
number = "14",
}