TY - JOUR
T1 - SHANK family on stem cell fate and development
AU - Liu, Xu
AU - Yuan, Mengmeng
AU - Lau, Benson Wui Man
AU - Li, Yue
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 82073832 to YL), Tianjin Natural Science Fund for Distinguished Young Scholars (No. 20JCJQJC00070 to YL, China), Tianjin Municipal Education Commission Scientific Research Project (No. 2019ZD11 to YL, China), and General Research Fund (No. 15105621 to BL) by University Grant Council (Hong Kong).
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/10/18
Y1 - 2022/10/18
N2 - SH3 and multiple ankyrin repeat domains protein (SHANK) 1, SHANK2, and SHANK3 encode a family of postsynaptic scaffolding proteins present at glutamatergic synapses and play a crucial role in synaptogenesis. In the past years, studies have provided a preliminary appreciation and understanding of the influence of the SHANK family in controlling stem cell fate. Here, we review the modulation of SHANK gene expression and their related signaling pathways, allowing for an in-depth understanding of the role of SHANK in stem cells. Besides, their role in governing stem cell self-renewal, proliferation, differentiation, apoptosis, and metabolism are explored in neural stem cells (NSCs), stem cells from apical papilla (SCAPs), and induced pluripotent stem cells (iPSCs). Moreover, iPSCs and embryonic stem cells (ESCs) have been utilized as model systems for analyzing their functions in terms of neuronal development. SHANK-mediated stem cell fate determination is an intricate and multifactorial process. This study aims to achieve a better understanding of the role of SHANK in these processes and their clinical applications, thereby advancing the field of stem cell therapy. [Figure not available: see fulltext.].
AB - SH3 and multiple ankyrin repeat domains protein (SHANK) 1, SHANK2, and SHANK3 encode a family of postsynaptic scaffolding proteins present at glutamatergic synapses and play a crucial role in synaptogenesis. In the past years, studies have provided a preliminary appreciation and understanding of the influence of the SHANK family in controlling stem cell fate. Here, we review the modulation of SHANK gene expression and their related signaling pathways, allowing for an in-depth understanding of the role of SHANK in stem cells. Besides, their role in governing stem cell self-renewal, proliferation, differentiation, apoptosis, and metabolism are explored in neural stem cells (NSCs), stem cells from apical papilla (SCAPs), and induced pluripotent stem cells (iPSCs). Moreover, iPSCs and embryonic stem cells (ESCs) have been utilized as model systems for analyzing their functions in terms of neuronal development. SHANK-mediated stem cell fate determination is an intricate and multifactorial process. This study aims to achieve a better understanding of the role of SHANK in these processes and their clinical applications, thereby advancing the field of stem cell therapy. [Figure not available: see fulltext.].
UR - http://www.scopus.com/inward/record.url?scp=85140053942&partnerID=8YFLogxK
U2 - 10.1038/s41419-022-05325-3
DO - 10.1038/s41419-022-05325-3
M3 - Review article
C2 - 36257935
AN - SCOPUS:85140053942
SN - 2041-4889
VL - 13
JO - Cell Death and Disease
JF - Cell Death and Disease
IS - 10
M1 - 880
ER -