@inproceedings{4f7b36c72cbb4f8c91f6c81b1c3b9b7b,
title = "SENSITIVE DIAGNOSIS OF BACTERIAL INFECTIONS WITH LABEL-FREE MICROFLUIDICS",
abstract = "Pathogens may hide inside immune cells to avoid the detection of human infectious diseases. We revealed that intracellular bacteria cause monocytes to become much stiffer and larger than healthy individuals. Hence, we introduced a label-free microchip that detects and quantifies monocytes with internalized pathogens (MIP) using inertial focusing. Different bacteria and clinical isolates were utilized to validate the device's functionality and set the infected sample threshold. The MIP platform can complete processing within 1.5 h. Our proof-of-concept shows that the MIP device has excellent prospects for diagnosing microbial infection.",
keywords = "Diagnosis, Intracellular pathogens, Label-free, Microfluidics",
author = "Junchen Liao and Chua, {Song Lin} and Khoo, {Bee Luan}",
note = "Funding Information: This study was supported by the Research Grants Council (RGC). This work was also supported by the City University of Hong Kong and the Hong Kong Polytechnic University, Environmental and Conservation Fund, and State Key Laboratory for Chemical Biology and Drug Discovery. Publisher Copyright: {\textcopyright} 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 ; Conference date: 10-10-2021 Through 14-10-2021",
year = "2021",
month = oct,
language = "English",
series = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "785--786",
booktitle = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}
