Abstract
In this study, a new non-toxic, biodegradable, biocompatible and water-soluble carboxylic curdlan bearing the dissociable COOH group in 100% purity, which was prepared by 4-acetamido-TEMPO-mediated oxidation, was hydrophobically modified by deoxycholic acid (DOCA) to attain novel amphiphilic curdlan derivatives (CCDs) for the preparation of nano-carriers for antitumor drug doxorubicin (DOX). Under the effect of ultrasonication, the carboxylic curdlan derivatives in water were self-aggregated into spherical nanoparticles with diameters ranging from 214. nm to 380. nm. The critical aggregation concentrations decreased from 0.047. mg/mL to 0.016. mg/mL with increasing DS of DOCA. DOX-loaded CCD nanoparticles were prepared in an aqueous medium with dialysis method. The DOX-CCD nanoparticles exhibited pH- and dose-dependent drug release profiles during in vitro release experiments. Moreover, the drug transport mechanism was Fickian diffusion according to the Ritger-Peppas model. The CCD nanoparticles might be explored as potential carriers for hydrophobic drugs with controlled release and delivery functions.
Original language | English |
---|---|
Pages (from-to) | 333-340 |
Number of pages | 8 |
Journal | International Journal of Biological Macromolecules |
Volume | 72 |
DOIs | |
Publication status | Published - 1 Dec 2014 |
Keywords
- Carboxylic curdlan
- Deoxycholic acid
- Self-aggregated nanoparticles
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Molecular Biology