Self-aggregated nanoparticles of carboxylic curdlan-deoxycholic acid conjugates as a carrier of doxorubicin

Jing Kun Yan, Hai Le Ma, Xia Chen, Juan Juan Pei, Zhen Bin Wang, Jianyong Wu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

22 Citations (Scopus)

Abstract

In this study, a new non-toxic, biodegradable, biocompatible and water-soluble carboxylic curdlan bearing the dissociable COOH group in 100% purity, which was prepared by 4-acetamido-TEMPO-mediated oxidation, was hydrophobically modified by deoxycholic acid (DOCA) to attain novel amphiphilic curdlan derivatives (CCDs) for the preparation of nano-carriers for antitumor drug doxorubicin (DOX). Under the effect of ultrasonication, the carboxylic curdlan derivatives in water were self-aggregated into spherical nanoparticles with diameters ranging from 214. nm to 380. nm. The critical aggregation concentrations decreased from 0.047. mg/mL to 0.016. mg/mL with increasing DS of DOCA. DOX-loaded CCD nanoparticles were prepared in an aqueous medium with dialysis method. The DOX-CCD nanoparticles exhibited pH- and dose-dependent drug release profiles during in vitro release experiments. Moreover, the drug transport mechanism was Fickian diffusion according to the Ritger-Peppas model. The CCD nanoparticles might be explored as potential carriers for hydrophobic drugs with controlled release and delivery functions.
Original languageEnglish
Pages (from-to)333-340
Number of pages8
JournalInternational Journal of Biological Macromolecules
Volume72
DOIs
Publication statusPublished - 1 Dec 2014

Keywords

  • Carboxylic curdlan
  • Deoxycholic acid
  • Self-aggregated nanoparticles

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

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