Selenium forms and dosages determined their biological actions in mouse models of Parkinson’s Disease

Chongchong SUN, Zhongrui Du, Xin Liu, Ye Yang, Sainan Zhou, Chong Li, XU CAO, QING ZHAO, Ka Hing Wong, Wenfang Chen (Corresponding Author), Xiaoli Dong (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

Selenium (Se) as an essential antioxidant trace element is reported to play a role in Parkinson’s disease (PD). However, there is a lack of systematic studies on different Se forms against PD. Our study aims to compare the neuroprotective effects of inorganic and organic Se in two classical PD mice models and investigate the underlying mechanisms for their potentially differential actions against PD. In this study, different dosages of inorganic sodium selenite (Se-Na) or organic sele-no-L-methionine (Se-Met) were fed to either acute or chronic PD mice model, their neuroprotective effects and mechanisms were explored and compared. Se-Na provided better neuroprotective ef-fects against PD than Se-Met at the same but relatively low Se dosage. Se-Na treatment could in-fluence GPX activities but not their mRNA expressions in the midbrain of PD mice. The enhanced GPX activities by Se-Na, but not Se-Met, in PD mice could be the major reason for the positive ac-tions of inorganic Se to prevent dopaminergic neuronal loss in this study. In vivo bio-distribution experiment found MPTP injection greatly changed Se bio-distribution in mice, which led to reversed alterations in bioavailability of Se-Met and Se-Na. Se-Na had higher bioavailability than Se-Met in PD mice, which could explain for its better neuroprotective effects than Se-Met. Our results proved that Se forms and dosages determined their biological actions against PD. Our study will provide valuable scientific evidences to researchers and/or medical professionals in using Se for the pre-vention and/or therapy of PD.
Original languageEnglish
Article number11
Number of pages12
JournalNutrients
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2023

Keywords

  • Parkinson's disease
  • selenium
  • sodium selenite
  • seleno-L-methionine
  • selenoproteins

ASJC Scopus subject areas

  • Neurology
  • Food Science
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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