Selective photodynamic eradication of senescent cells with a β-galactosidase-activated photosensitiser

Junlong Xiong, Ying Kit Cheung, Wing Ping Fong, Clarence T.T. Wong, Dennis K.P. Ng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

A β-galactosidase-responsive photosensitiser has been designed and synthesised. It contains a galactosyl substrate, a boron dipyrromethene-based photosensitising unit and a black hole quencher 2 connected via an AB2-type self-immolative linker. This novel photosensitiser can be selectively activated by the senescence-associated β-galactosidase in senescent cells, leading to restoration in fluorescence emission and effective killing of the cells via photodynamic action.

Original languageEnglish
Pages (from-to)3471-3474
Number of pages4
JournalChemical Communications
Volume59
Issue number23
DOIs
Publication statusPublished - 24 Feb 2023

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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