Selective cytotoxic lesions of the retrohippocampal region produce a mild deficit in social recognition memory

D. Bannerman, M. Lemaire, Kay Yan Benjamin Yee, S. Iversen, C. Oswald, M. Good, J. Rawlins

Research output: Journal article publicationJournal articleAcademic researchpeer-review

42 Citations (Scopus)

Abstract

Although a number of studies have implicated the hippocampal formation in social recognition memory in the rat, a recent study in this laboratory has demonstrated that selective cytotoxic lesions, confined to the hippocampus proper (encompassing the four CA subfields and the dentate gyrus), are without effect on this behaviour. This finding suggests that the hippocampus proper does not subserve social recognition memory in the rat, but does not preclude the possibility that other areas of the hippocampal formation, such as the entorhinal cortex or subiculum, could support this form of learning. The present study addressed this issue by examining the effects of selective cytotoxic retrohippocampal (RHR) lesions (including both the entorhinal cortex and subiculum) on social recognition memory in the rat. RHR lesions produced a mild social recognition memory impairment, although lesioned animals still displayed a reduction in investigation time between the first and second exposure to the juvenile. This result is consistent with other studies which have implicated the retrohippocampal or parahippocampal area in olfactory recognition memory processes. It also suggests, however, that other areas, out-with the retrohippocampal region, are also likely to play an important role in social recognition memory.
Original languageEnglish
Pages (from-to)395-401
Number of pages7
JournalExperimental Brain Research
Volume142
Issue number3
DOIs
Publication statusPublished - 12 Feb 2002
Externally publishedYes

Keywords

  • Cytotoxic lesions
  • Entorhinal cortex
  • Hippocampal formation
  • Retrohippocampal region
  • Social recognition memory
  • Subiculum

ASJC Scopus subject areas

  • Neuroscience(all)

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