Secondary degeneration after partial optic nerve injury and possible neuroprotective effects of lycium barbarum (Wolfberry)

Hong Ying Li, Ho Lung Henry Chan, Patrick Hw Chu, Raymond Chuen Chung Chang, Kwok Fai So

Research output: Chapter in book / Conference proceedingChapter in an edited book (as author)Academic researchpeer-review

4 Citations (Scopus)

Abstract

Partial optic nerve transection (PONT) model was established in the last decade and was good for studying secondary degeneration in retinas and optic nerves. The results from the published papers about PONT showed that the mechanisms—apoptosis, necrosis, autophagy, oxidative stress, calcium overload, mitochondria, activation of c-jun, water channel change, and glial cells (microglia, astrocytes and oligodendrocytes)—were involved in secondary degeneration after PONT. In addition to the cell bodies and the axons of retinal ganglion cells (RGCs), other cells in the layers outside the ganglion cell layer were also affected according to the measurement of multifocal electroretinogram (mfERG) by our group. Lycium barbarum (L. barbarum) is a traditional medicine in the oriental world and has long been used as a functional food and for medicinal purposes. The data from our group and others showed that the polysaccharides extracted from L. barbarum (LBP) were neuroprotective in different animal models, including the PONT model. Our results showed that LBP could inhibit secondary degeneration of the cell bodies of RGCs rather than primary degeneration as well as preserve the function of retinas measured by mfERG. These effects are related with the antioxidant function of LBP, inhibition of c-jun N-terminal kinase (JNK) pathway in the retinas after PONT. Other possible mechanisms involved in LBP’s neuroprotective effects for secondary degeneration are immunomodulatory effects, preservation of synapses, and modulation of autophagy.
Original languageEnglish
Title of host publicationLycium Barbarum and Human Health
PublisherSpringer Netherlands
Pages135-151
Number of pages17
ISBN (Electronic)9789401796583
ISBN (Print)9789401796576
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Lycium barbarum
  • Neuroprotection
  • Optic nerve
  • Secondary degeneration

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)
  • Neuroscience(all)

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