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SearchRAG: Can Search Engines Be Helpful for LLM-Based Medical Question Answering?

  • Yucheng Shi
  • , Tianze Yang
  • , Canyu Chen
  • , Quanzheng Li
  • , Tianming Liu
  • , Xiang Li
  • , Ninghao Liu

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Large Language Models (LLMs) have shown remarkable capabilities in general domains but often struggle with tasks requiring specialized knowledge. Conventional Retrieval-Augmented Generation (RAG) techniques typically retrieve external information from static knowledge bases, which can be outdated or incomplete, missing fine-grained clinical details essential for accurate medical question answering. In this work, we propose SearchRAG, a novel framework that overcomes these limitations by leveraging real-time search engines. Our method employs synthetic query generation to convert complex medical questions into search-engine-friendly queries and utilizes uncertainty-based knowledge selection to filter and incorporate the most relevant and informative medical knowledge into the LLM's input. Experimental results demonstrate that our method significantly improves response accuracy in medical question answering tasks, particularly for complex questions requiring detailed and up-to-date knowledge. We provide our code here11https://github.com/sycny/SearchRAG.

Original languageEnglish
Title of host publicationProceedings - 2025 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2025
EditorsJuan Liu, Jingshan Huang, Xiaowo Wang, Fa Zhang, Xiufen Zou, Tian Tian, Xiaohua Hu, Bin Hu, Yi Xiong
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages4051-4056
Number of pages6
ISBN (Electronic)9798331515577
DOIs
Publication statusPublished - Dec 2025
Event2025 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2025 - Wuhan, China
Duration: 15 Dec 202518 Dec 2025

Publication series

NameProceedings - 2025 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2025

Conference

Conference2025 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2025
Country/TerritoryChina
CityWuhan
Period15/12/2518/12/25

Keywords

  • LLMs
  • Medical QA
  • RAG
  • Search Engine

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Vision and Pattern Recognition
  • Biomedical Engineering
  • Modelling and Simulation
  • Medicine (miscellaneous)
  • Health Informatics

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