Screening for post-miscarriage psychiatric morbidity

Ingrid H. Lok, Dominic T.S. Lee, Shing Kai Yip, Tan Lei Shek, Wing H. Tam, Tony K.H. Chung

Research output: Journal article publicationJournal articleAcademic researchpeer-review

23 Citations (Scopus)


Objective The purpose of this study was to evaluate 12-item General Health Questionnaire (GHQ-12) in screening for psychiatric morbidity after miscarriage. Study design A prospective cohort study was carried out involving 222 patients. Six weeks after miscarriage, the GHQ-12 was applied. Psychiatric "case" or "non-case" was diagnosed by the psychiatrist with use of the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-III-R. The patients were computer randomized into Groups A or B. A receiver operating characteristic (ROC) curve was constructed for Group A. The optimal cutoff value of GHQ-12 was determined, and this value was applied to Group B. The test characteristics were assessed. Results Twenty-seven patients were found to be psychiatric cases. An ROC with area under curve of 0.93 (95% CI 0.87-0.99, P<.001) was constructed. The best GHQ-12 cutoff score was ≥4 in detecting psychiatric caseness. A sensitivity of 83%, specificity of 90%, positive predictive value of 50%, and negative predictive value of 98% were obtained. Conclusion GHQ-12 is an effective screening tool in detecting psychiatric morbidity after miscarriage.
Original languageEnglish
Pages (from-to)546-550
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number2
Publication statusPublished - 1 Aug 2004
Externally publishedYes


  • Depression
  • GHQ-12
  • Miscarriage
  • Psychiatric morbidity
  • Screening

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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