Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice

S. Y. Pan, Yifan Han, P. R. Carlier, Y. P. Pang, D. H.F. Mak, B. Y.H. Lam, K. M. Ko

Research output: Journal article publicationJournal articleAcademic researchpeer-review

22 Citations (Scopus)

Abstract

Intragastric administration (100-200 μmol/kg) of tacrine (THA) or bis(7)-THA could cause an acute and dose-dependent increase in plasma alanine aminotransferases activity in mice at 6 h after the drug administration. The increase in plasma enzyme activity was associated with an increase in hepatic malondialdehyde level, an indirect index of oxidative tissue damage. Pretreating mice with schisandrin B (Sch B), an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, at a daily dose of 0.125-0.5 mmol/kg for 3 days protected against the THA/bis(7)-THA induced hepatic oxidative damage in a dose-dependent manner. Sch B treatment (0.025-0.5 mmol/kg/day × 5) also enhanced the passive avoidance-response in mice as assessed by the step-through task experiment. The ensemble of results suggests that Sch B may be useful for reducing the potential hepatotoxicity of THA/bis(7)-THA in anti-Alzheimer's therapy.
Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalPlanta Medica
Volume68
Issue number3
DOIs
Publication statusPublished - 13 Apr 2002
Externally publishedYes

Keywords

  • Bis(7)-tacrine
  • Cognitive enhancement
  • Hepatotoxicity
  • Schisandra chinensis
  • Schisandraceae
  • Schisandrin B
  • Tacrine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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