Network adaptation is essential for the efficient operation of Cloud-RANs. Unfortunately, it leads to highly intractable mixed-integer nonlinear programming problems. Existing solutions typically rely on convex relaxation, which yield performance gaps that are difficult to quantify. Meanwhile, global optimization algorithms such as branch-and-bound can find optimal solutions but with prohibitive computational complexity. In this paper, to obtain near-optimal solutions at affordable complexity, we propose to approximate the branch-and-bound algorithm via machine learning. Specifically, the pruning procedure in branch-and-bound is formulated as a sequential decision problem, followed by learning the oracle's action via imitation learning. A unique advantage of this framework is that the training process only requires a small dataset, and it is scalable to problem instances with larger dimensions than the training setting. This is achieved by identifying and leveraging the problem-size independent features. Numerical simulations demonstrate that the learning based framework significantly outperforms competing methods, with computational complexity much lower than the traditional branch-and-bound algorithm.