SARI prevents ocular angiogenesis and inflammation in mice

Wenqiu Zhang, Lei Dai, Xun Li, Yiming Li, Maurice Keng Hung Yap, Longqian Liu, Hongxin Deng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

SARI (Suppressor of AP-1, regulated by IFN-β) is known to play an important role in some systemic disease processes such an inflammatory conditions and cancer. We hypothesize that SARI may also play a role in ocular diseases involving inflammation and neovascularization. To explore our hypothesis, further, we investigated an endotoxin-induced uveitis (EIU) and experimental argon laser-induced choroidal neovascularization (CNV) model in SARI wild-type (SARIWT) and SARI-deficient (SARI−/−) mice. Through imaging, morphological and immunohistochemical (IHC) studies, we found that SARI deficiency exacerbated the growth of CNV. More VEGF-positive cells were presented in the retina of SARI−/− mice with CNV. Compared to SARIWT mice, more inflammatory cells infiltrated the ocular anterior segment and posterior segments in SARI−/− mice with EIU. Collectively, the results point to a potential dual functional role of SARI in inflammatory ocular diseases, suggesting that SARI could be a potential therapy target for ocular inflammation and neovascularization.
Original languageEnglish
Pages (from-to)4341-4349
Number of pages9
JournalJournal of Cellular and Molecular Medicine
Volume24
Issue number7
Early online date2 Mar 2020
DOIs
Publication statusPublished - 20 Apr 2020

Keywords

  • Suppressor of AP-1
  • Uveitis
  • age-related macular degeneration
  • choroidal neovascularization
  • regulated by IFN-β
  • vascular endothelial growth factor

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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