Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles

Ling He, Philip Wai Hong Chan, Wai Man Tsui, Wing Yiu Yu, Chi Ming Che

Research output: Journal article publicationJournal articleAcademic researchpeer-review

66 Citations (Scopus)

Abstract

(Equation Presented) Ruthenium(II) porphyrin-catalyzed amidation of aromatic heterocycles with iminoiodanes under mild conditions (CH2Cl2, 4 Å molecular sieves, ultrasound, 40°C) was achieved in moderate to good yields (up to 84%) and conversions (up to 99%). Only the N,N-ditosylamidated product was obtained for reactions involving heteroarenes, where X = O, S, or NTs. N-Alkyl- and N-aryl-substituted pyrroles, on the other hand, were shown to give the 3,4-diaminated adduct.
Original languageEnglish
Pages (from-to)2405-2408
Number of pages4
JournalOrganic Letters
Volume6
Issue number14
DOIs
Publication statusPublished - 8 Jul 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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