Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase

Keyphrases

• In Cancer 100%
• Cancer Cells 100%
• Inducer 100%
• Thioredoxin Reductase 100%
• TrxR 100%
• Ruthenium Polypyridyl Complexes 100%
• ROS-mediated Apoptosis 100%
• Ruthenium 66%
• 1,10-Phenanthroline 50%
• Phen 33%
• Antiproliferative Activity 33%
• Cancer Treatment 33%
• Cisplatin 33%
• Targeted Agents 16%
• Mitochondria 16%
• Ruthenium Complexes 16%
• Metal Complexes 16%
• 2,2′-Bipyridine 16%
• Planarity 16%
• Nicotinamide Adenine Dinucleotide Phosphate (NADPH) 16%
• Inhibitory Effect 16%
• Anticancer Drugs 16%
• Apoptosis 16%
• DNA Fragmentation 16%
• Apoptosis Induction 16%
• Role in Cancer 16%
• Inhibitory Potency 16%
• DNA Damage 16%
• Cancer Cell Growth 16%
• In Vitro Anticancer Activity 16%
• Cell Population 16%
• Cancer Progression 16%
• Human Melanoma Cells 16%
• Vascular Endothelial Growth Factor Receptor (VEGFR) 16%
• Auranofin 16%
• In Vitro Evaluation 16%
• Nuclear Condensation 16%
• P53 Phosphorylation 16%
• TrxR Inhibitor 16%
• Diimine Ligands 16%
• Imidazole-4 16%
• P53 Inhibitor 16%
• Selenoenzymes 16%
• Mitochondrium 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Thioredoxin Reductase 100%
• Cytochrome C Oxidase 100%
• 1,10 Phenanthroline 75%
• Cisplatin 50%
• Antiproliferative Activity 50%
• Cancer Growth 50%
• Auranofin 25%
• 2,2' Bipyridine 25%
• Ruthenium Complex 25%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate 25%
• Protein P53 25%
• Metal Complex 25%
• Melanoma 25%
• Protein Kinase B 25%
• Imidazole 25%
• Anticancer Drug 25%

Chemistry

• Ruthenium 100%
• Reactive Oxygen Species 100%
• Thioredoxin 100%
• 1,10-phenanthroline 42%
• Antiproliferative 28%
• Cisplatin 28%
• DNA 28%
• Antineoplastic Agent 14%
• Bipyridine 14%
• Condensation 14%
• NADPH 14%
• Imidazole 14%
• phosphorylation 14%
• Auranofin 14%