Ruthenium-catalyzed oxidation of alkenes, alkynes, and alcohols to organic acids with aqueous hydrogen peroxide

Chi Ming Che, Wing Ping Yip, Wing Yiu Yu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

44 Citations (Scopus)


A protocol that adopts aqueous hydrogen peroxide as a terminal oxidant and [(Me3tacn)(CF3CO2)2RuIII(OH2)]CF3CO2(1; Me3tacn = l,4,7-trimethyl-l,4,7-triazacyclononane) as a catalyst for oxidation of alkenes, alkynes, and alcohols to organic acids in over 80% yield is presented. For the oxidation of cyclohexene to adipic acid, the loading of 1 can be lowered to 0.1 mol%. On the one-mole scale, the oxidation of cyclohexene, cyclooctene, and 1-octanol with 1 mol% of 1 produced adipic acid (124g, 85% yield), suberic acid (158 g, 91% yield), and 1-octanoic acid (129 g, 90% yield), respectively. The oxidative C=C bondcleavage reaction proceeded through the formation of cis- and trans-diol intermediates, which were further oxidized to carboxylic acids via C-C bond cleavage. KGaA.
Original languageEnglish
Pages (from-to)453-458
Number of pages6
JournalChemistry - An Asian Journal
Issue number3
Publication statusPublished - 5 Oct 2006
Externally publishedYes


  • Alcohols
  • Alkenes
  • Alkynes
  • Oxidation
  • Ruthenium

ASJC Scopus subject areas

  • Chemistry(all)

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